摘要
目的:糖尿病(DM)和糖尿病视网膜病变(DR)与氧化应激有关,类胡萝卜素具有抗氧化特性。本研究旨在测试血清类胡萝卜素浓度与糖尿病和心血管疾病风险之间的关系。 方法:对中国城市人口进行横断面调查。本研究共纳入747名受试者,包括272名DR患者、190名无视网膜病变的糖尿病患者和285名非糖尿病健康对照者。通过问卷调查确定人口和生活方式特征。所有参与者都完成了一般的物理和眼科检查。用高效液相色谱法测定血清类胡萝卜素含量。用已知危险因子的logistic回归评估血清类胡萝卜素与糖尿病和DR的关联。用单变量线性回归分析血清类胡萝卜素与候选因素的相关性分析。 结果:测定各组血清中维生素A(PVA)类胡萝卜素和非PVA类胡萝卜素的含量,并进行比较。糖尿病患者α-胡萝卜素水平显著低于非糖尿病对照组,β胡萝卜素水平显著低于糖尿病对照组。相反,对ββ-隐黄素,番茄红素含量,叶黄素和玉米黄质是比较不同组间。调整混杂因素后,β-胡萝卜素浓度与糖尿病风险降低(OR(95% CI):0.56(0.34,0.91),P = 0.02)和α-胡萝卜素有关的风险减少非吸烟者的DR(OR(95% CI):0.41(0.17,0.99),P = 0.048)。糖化血红蛋白与类胡萝卜素无显著相关(P>0.05)。年龄、性别、体重指数、吸烟、运动量与血清类胡萝卜素呈显著正相关(p<0.05)。 结论:血清β-胡萝卜素对糖尿病有保护作用,α-胡萝卜素可能是非吸烟者的保护因子。
关键词: 糖尿病,糖尿病视网膜病变,血清类胡萝卜素,非吸烟者,横断面调查,中国城市人群。
Current Molecular Medicine
Title:Serum Carotenoids and Risks of Diabetes and Diabetic Retinopathy in a Chinese Population Sample
Volume: 17 Issue: 4
关键词: 糖尿病,糖尿病视网膜病变,血清类胡萝卜素,非吸烟者,横断面调查,中国城市人群。
摘要: Objective: Diabetes mellitus (DM) and diabetic retinopathy (DR) are associated with oxidative stress and carotenoids have antioxidant properties. This study aimed to test the relationship between serum carotenoid concentrations and the risk for DM and DR.
Methods: This is a cross-sectional study of the Chinese urban population. A total of 747 subjects, consisting of 272 DR patients, 190 diabetic patients without retinopathy, and 285 non-diabetes mellitus healthy controls, were recruited to this study. Demographic and lifestyle characteristics were ascertained by questionnaire. General physical and ophthalmic examinations were completed for all participants. Serum carotenoids were measured by high-performance liquid chromatography (HPLC). The associations of serum carotenoids with DM and DR were assessed by logistic regression with adjustment of known risk factors. The correlation analyses of serum carotenoids with the candidate influence factors were assessed using the single variable linear regression.
Results: Both pro-vitamin A (PVA) carotenoids and non-PVA carotenoids in the serum were measured and compared between different groups. Levels of α-carotene were significantly lower in DR patients and β-carotene were significantly lower in DM patients as compared to non DM healthy control group. In contrast, levels of β-cryptoxanthin, lycopene, lutein and zeaxanthin were comparable among different groups. After adjusting for confounding factors, β-carotene concentration was associated with reduced risk for DM (OR (95%CI): 0.56 (0.34, 0.91), P=0.02) and α-carotene was associated with reduced risk for DR in non-smokers (OR (95%CI): 0.41 (0.17, 0.99), P=0.048). No significant association was found between hemoglobin A1c and any carotenoids (P>0.05). Significantly associations with serum carotenoids were found in age, sex, BMI, smoking, and exercise (P<0.05).
Conclusion: Serum β-carotene may have a protective effect on DM and α-carotene may be a protective factor for DR in non-smokers.
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Cite this article as:
Serum Carotenoids and Risks of Diabetes and Diabetic Retinopathy in a Chinese Population Sample, Current Molecular Medicine 2017; 17 (4) . https://dx.doi.org/10.2174/1566524017666171106112131
DOI https://dx.doi.org/10.2174/1566524017666171106112131 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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