摘要
目的:以自我为中心(受试者 - 对象)和异于中心(对象 - 对象)空间表征的缺陷为主,具有以异位为主的障碍,表现为阿尔茨海默病(AD)的第一阶段。 方法:为了识别阿尔茨海默病转换的早期认知体征,一些研究集中在遗忘 - 轻度认知障碍(aMCI)上,通过报告两个参考框架,尤其是异构中心框架的改变。但是,我们所处的空间环境需要两个参考框架的配合。这种合作的过程意味着我们不断从非中心框架转向自我中心框架,反之亦然。这提出了转换能力的改变是否也可以表征AD的早期认知标记的问题,潜在地适合于检测从aMCI到痴呆的转换。在这里,我们比较了AD和aMCI患者与正常对照(NC)在自我 - 同步切换空间记忆任务。该任务评估了使用转换(Ego-Allo,Allo-Ego)和不转换(Ego-Ego,Allo-Allo)口头判断记忆刺激之间相对距离的能力。 结果:这项研究的新发现是由aMCI和AD在从异于中心的参考框架转换为自我中心的整齐的损害。有趣的是,在第一个参照框架是以自我为中心的aMCI中,异质中心赤字出现了衰减。 结论:这导致我们得出这样的结论:在MCI中,异位中心的缺陷在临床上并不总是可以检测到的,因为当第一个参考框架是以身体为中心的时候,损伤可能被掩盖了。另外,AD和aMCI也揭示了非转换条件下的异质性赤字。这些发现表明,转换改变将出现在海马和后内侧区域的损伤以及蓝斑去甲肾上腺素系统或前额叶皮层中的同时失调。
关键词: 自我中心 - 异性中心表征,遗忘型轻度认知障碍,阿尔茨海默病,转换/不转换能力,标题定向障碍,视觉空间记忆障碍。
Current Alzheimer Research
Title:Allocentric to Egocentric Spatial Switching: Impairment in aMCI and Alzheimer's Disease Patients?
Volume: 15 Issue: 3
关键词: 自我中心 - 异性中心表征,遗忘型轻度认知障碍,阿尔茨海默病,转换/不转换能力,标题定向障碍,视觉空间记忆障碍。
摘要: Objective: Deficits in egocentric (subject-to-object) and allocentric (object-to-object) spatial representations, with a mainly allocentric impairment, characterize the first stages of the Alzheimer's disease (AD).
Methods: To identify early cognitive signs of AD conversion, some studies focused on amnestic-Mild Cognitive Impairment (aMCI) by reporting alterations in both reference frames, especially the allocentric ones. However, spatial environments in which we move need the cooperation of both reference frames. Such cooperating processes imply that we constantly switch from allocentric to egocentric frames and vice versa. This raises the question of whether alterations of switching abilities might also characterize an early cognitive marker of AD, potentially suitable to detect the conversion from aMCI to dementia. Here, we compared AD and aMCI patients with Normal Controls (NC) on the Ego-Allo- Switching spatial memory task. The task assessed the capacity to use switching (Ego-Allo, Allo-Ego) and non-switching (Ego-Ego, Allo-Allo) verbal judgments about relative distances between memorized stimuli.
Results: The novel finding of this study is the neat impairment shown by aMCI and AD in switching from allocentric to egocentric reference frames. Interestingly, in aMCI when the first reference frame was egocentric, the allocentric deficit appeared attenuated.
Conclusion: This led us to conclude that allocentric deficits are not always clinically detectable in aMCI since the impairments could be masked when the first reference frame was body-centred. Alongside, AD and aMCI also revealed allocentric deficits in the non-switching condition. These findings suggest that switching alterations would emerge from impairments in hippocampal and posteromedial areas and from concurrent dysregulations in the locus coeruleus-noradrenaline system or pre-frontal cortex.
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Cite this article as:
Allocentric to Egocentric Spatial Switching: Impairment in aMCI and Alzheimer's Disease Patients?, Current Alzheimer Research 2018; 15 (3) . https://dx.doi.org/10.2174/1567205014666171030114821
DOI https://dx.doi.org/10.2174/1567205014666171030114821 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
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