摘要
目的:顶叶下小叶(IPL)在许多高级认知过程中,如视觉-运动转换、工具使用或工具制作等,都具有重要的意义。轻度认知障碍患者患有阿尔茨海默病(AD)的主要风险是视力或语用能力的损害,这是众所周知的临床特征。提高脑电α3/α2频率比值在患有老年痴呆症(AD)的MCI患者中检测到ER。 方法:探讨MCI患者α3/α2功率比值与皮质IPL大小的关系。74例MCI患者行脑电记录和MRI扫描。α3/α2大鼠除皮质大小外,还计算了每个病人的Io值。已获得三个MCI组,以保持α3/alpha 2比值的增长。皮质厚度的巨大差异计算各组间的Ess。高的α3/α2功率比组的皮质损耗比其他组更大,尤其是在边缘上的回神经和前脑区。半球( hemisphere的名词复数 ). 结果:我们的结果揭示了IPL在早期阿尔茨海默病(AD)经典改变中可能发挥的作用。 结论:α3/α2功率比值的升高可作为早期AD的可靠指标。
关键词: 轻度认知障碍,阿尔茨海默氏病,脑电图,MRI,痴呆,下小体。
Current Alzheimer Research
Title:Increase of EEG Alpha3/Alpha2 Power Ratio Detects Inferior Parietal Lobule Atrophy in Mild Cognitive Impairment
Volume: 15 Issue: 5
关键词: 轻度认知障碍,阿尔茨海默氏病,脑电图,MRI,痴呆,下小体。
摘要: Objective: The inferior parietal lobule (IPL) has been implicate in many higher cognitive processes, as visuo-motor transformations, tool use or tool making. In subjects with mild cognitive impairment (MCI) at major risk to develop Alzheimer' Disease (AD) an impairment of subtle visuomotor or praxic abilities is a well-known clinical feature. Enhance of the ratio of EEG alpha3/alpha2 frequency power was detected in subjects with MCI who will transform in Alzheimer's disease (AD).
Methods: We explored of the association of alpha3/alpha2 power ratio with cortical size of IPL in patients with MCI. 74 subjects with MCI undergone EEG recording and MRI scans. Alpha3/alpha2 power ratio in addition to cortical size had been computed for each patient. Three MCI groups had been acquired in keeping with growing tertile values of alpha3/alpha2 ratio. Huge difference of cortical thickness among the groups was calculated. Higher alpha3/alpha2 power ratio group had broader cortical loss compared to other teams on the IPL, particularly in the Supramarginal Gyrus, and Precuneus on both hemispheres.
Results: Our results unveil the possible part that the IPL could play in determining the classic alterations of early Alzheimer's disease (AD).
Conclusion: Finally, the rise of alpha3/alpha2 power ratio detected a focused anatomo-functional association that could be a reliable marker of incipient AD.
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Increase of EEG Alpha3/Alpha2 Power Ratio Detects Inferior Parietal Lobule Atrophy in Mild Cognitive Impairment, Current Alzheimer Research 2018; 15 (5) . https://dx.doi.org/10.2174/1567205014666171030105338
DOI https://dx.doi.org/10.2174/1567205014666171030105338 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
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