摘要
由于经济负担和与健康有关的问题，尼古丁依赖已逐渐成为发达国家和发展中国家最重要的社区健康利益。精神分裂症患者吸烟明显高于一般人群。尼古丁依赖不仅与公众压力有关，而且在精神分裂症患者中，吸烟给管理带来了重大挑战。尼古丁可能会降低精神药理学药物在体内的生物利用度。这两种双重干扰，即两种临床条件并存，可能阻碍同时吸烟的精神分裂症患者的精神症状的缓解。本综述的目的是强调药物治疗方案和策略对精神分裂症尼古丁依赖患者的作用，重点是潜在的神经生物学过程。讨论了尼古丁替代治疗(去甲肾上腺素-多巴胺再摄取抑制)如安非他酮和选择性部分激动剂α4β2和全α7烟碱乙酰胆碱受体(如伐伦克林)的作用。尼古丁依赖精神分裂症患者理想的药物靶点选择是促进更好的治疗联盟的关键。
关键词: 尼古丁依赖，精神分裂症，治疗方案，吸烟，精神活性药物，药物靶点。
图形摘要
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