心房颤动管理的新进展--阿皮卡班的作用

Title:New Advances in Atrial Fibrillation Management: The Role of Apixaban

Volume: 19 Issue: 6

关键词: 阿皮卡班，心房颤动，新型口服抗凝剂，中风，大出血，维生素K拮抗剂。

摘要: Background: Prevention of stroke is a pivotal intervention in the management of patients with atrial fibrillation (AF). Because of the difficulties of safely implementing Vitamin K Antagonists in all patients, there has been a growing interest in improving the pharmacological management of AF with newer antithrombotic agents. The new oral anticoagulants (NOACs) have been developed to overcome the limitations and improve the efficacy of the conventional oral anticoagulant drugs. Among the NOACs, apixaban - a very specific antagonist of activated factor Xa – has pharmacokinetic and pharmacodynamic properties that allow significant efficacy in AF management.

Objective: The aim of this review is to summarise the available data on the efficacy of apixaban in patients with AF, with a particular focus on the implications for its clinical management.

Results and Conclusion: Clinical application of apixaban in subgroups of patients with AF is still under investigation and some contraindications should be taken into account. Despite these limitations, apixaban is an effective alternative to warfarin and aspirin for stroke prevention in AF, with encouraging evidence also in terms of adherence to treatment.

Cite this article as:

New Advances in Atrial Fibrillation Management: The Role of Apixaban, Current Drug Targets 2018; 19 (6) . https://dx.doi.org/10.2174/1389450118666171013095413