摘要
背景:自体细胞治疗是一种在不同疾病条件下血管再生的新的治疗方法,实验和临床研究表明,包括内皮祖细胞在内的前血管生成细胞在治疗冠心病和外周动脉疾病方面具有潜在的治疗潜力。 目的:总结外周动脉疾病、缺血性心脑血管疾病、糖尿病微血管并发症和炎症性风湿病患者应用或动员PC的治疗潜力。方法:对文献数据库进行检索,查阅临床前和临床模型中PC在血管再生中的作用的同行复习研究文献。 结果:在不同的临床试验中,已报道了缺血症状的改善,并评价了PC对严重肢体缺血的治疗作用。然而,在这种情况下,元分析的对比结果质疑基于pc的方法的长期临床效果。临床前研究和临床试验证实了PC治疗缺血性心脑血管疾病的安全性和可行性,同时对临床硬结局有好处的证据尚不确定。尽管积累的实验结果支持PC在糖尿病视网膜病变中的治疗作用,但缺乏随机临床试验的结果。PC治疗是否可以限制早期动脉粥样硬化,降低炎症性风湿病的心血管风险,需要进一步研究。结论:虽然PC的潜在临床应用正在积累,但也有证据表明自体PC治疗具有多重局限性。因此,为了提高细胞治疗应用的有效性,有必要采取旨在提高PC活性和血管生成功能的新策略。
关键词: 血管生成细胞,内皮祖细胞,周围动脉疾病,缺血性心脏病,心力衰竭,脑血管病,糖尿病,微血管,风湿病,细胞治疗,炎症。
Current Medicinal Chemistry
Title:Autologous Cell Therapy for Vascular Regeneration: The Role of Proangiogenic Cells
Volume: 25 Issue: 35
关键词: 血管生成细胞,内皮祖细胞,周围动脉疾病,缺血性心脏病,心力衰竭,脑血管病,糖尿病,微血管,风湿病,细胞治疗,炎症。
摘要: Background: Autologous cell therapy represents a novel treatment option for vascular regeneration in different disease conditions, with experimental and clinical studies indicating a therapeutic potential for proangiogenic cells (PCs), including endothelial progenitor cells, in the treatment of coronary and peripheral artery disease.
Objective: To provide a summary of the therapeutic potential of PCs administration or mobilization in peripheral artery disease, ischemic heart and cerebrovascular diseases, diabetic microvascular complications and inflammatory rheumatic diseases.
Methods: We undertook a search of bibliographic databases for peer-reviewed research literature on the role of PCs in vascular regeneration in preclinical and clinical models.
Results: Improvement of ischemic symptoms has been reported in different trials evaluating PCs for the treatment of critical limb ischemia. However, in this setting, contrasting results from meta-analyses question the long-term clinical efficacy of PC-based approaches. Preclinical studies and clinical trials support the safety and feasibility of PC therapy in the treatment of ischemic heart and cerebrovascular diseases, while evidence indicating a benefit on hard clinical outcomes is uncertain. Despite accumulating experimental results support a therapeutic role for PCs in diabetic retinopathy, results from randomized clinical trials are lacking. Whether PC therapy may limit premature atherosclerosis and reduce cardiovascular risk in inflammatory rheumatic diseases needs to be investigated.
Conclusion: Although the potential clinical applications of PCs are accumulating, there is also evidence of multiple limitations for autologous PC therapy. Thus, novel strategies aimed at improving PC viability and angiogenic function are warranted in order to improve the efficacy of cell therapy applications.
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Cite this article as:
Autologous Cell Therapy for Vascular Regeneration: The Role of Proangiogenic Cells, Current Medicinal Chemistry 2018; 25 (35) . https://dx.doi.org/10.2174/0929867324666171012111603
DOI https://dx.doi.org/10.2174/0929867324666171012111603 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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