摘要
宫颈癌是女性中第二常见的癌症。宫颈癌的标准治疗方案包括化疗、手术和放射治疗。影响和毒性。以肿瘤为靶点的抗癌药物可能是从治疗中获得最佳效果和提高生活质量的最合适的策略之一。雷克基于纳米载体的药物传递系统由于其独特的特性,在抗癌药物的传递方面得到了广泛的研究。除了关于解剖学的意义介绍了宫颈癌NCE的各种局部给药策略,如凝胶、纳米粒子、高分子薄膜、棒和晶圆、脂质基纳米载体等。局部d地毯递送系统允许被动药物靶向导致高药物浓度的目标地点。此外,他们可以定制,以实现持续和控制释放行为,潜艇。改善治疗效果,减少副作用。本文综述了治疗宫颈癌药物传递策略的研究进展。
关键词: 宫颈癌,药物输送系统,药物靶向,局部输送,纳米载体,肠外途径。
图形摘要
Current Cancer Drug Targets
Title:Development of Drug Targeting and Delivery in Cervical Cancer
Volume: 18 Issue: 8
关键词: 宫颈癌,药物输送系统,药物靶向,局部输送,纳米载体,肠外途径。
摘要: Cervical cancer is the second most common cancer in women. Standard treatment options available for cervical cancer include chemotherapy, surgery and radiation therapy associated with their own side effects and toxicities. Tumor-targeted delivery of anticancer drugs is perhaps one of the most appropriate strategies to achieve optimal outcomes from the treatment and improve the quality of life. Recently nanocarriers based drug delivery systems owing to their unique properties have been extensively investigated for anticancer drug delivery. In addition to that addressing the anatomical significance of cervical cancer, various local drug delivery strategies for the cancer treatment are introduced like: gels, nanoparticles, polymeric films, rods and wafers, lipid based nanocarrier. Localized drug delivery systems allow passive drug targeting results in high drug concentration at the target site. Further they can be tailor made to achieve both sustained and controlled release behavior, substantially improving therapeutic outcomes and minimizing side effects. This review summarizes the meaningful advances in drug delivery strategies to treat cervical cancer.
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Cite this article as:
Development of Drug Targeting and Delivery in Cervical Cancer, Current Cancer Drug Targets 2018; 18 (8) . https://dx.doi.org/10.2174/1568009617666171009165105
DOI https://dx.doi.org/10.2174/1568009617666171009165105 |
Print ISSN 1568-0096 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5576 |
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