摘要
文献中描述的许多含有苯并噻唑支架的化合物对几种革兰氏阳性和革兰氏阴性细菌以及结核分枝杆菌都有很好的活性。以苯并噻唑为基础的抗菌化合物结合细菌细胞中不同的生物靶点,已被证明是对细菌细胞中的重要过程(如细胞壁合成、细胞分裂和DNA复制)起重要作用的酶的抑制剂,或对关键细胞的不同生物合成途径起重要作用。细菌细胞中的磅数,如组氨酸和生物素的生物合成。本文就苯并噻唑类化合物与细菌细胞靶点的特异性相互作用进行了综述。我们评估了苯并噻唑支架在发现新的抗菌化合物中的重要性,苯并噻唑类化合物对抗耐药菌株的潜力,抗菌活性的优化,以及苯并噻唑类抗菌药物的未来前景。
关键词: 苯并噻唑,抗菌,细菌耐药性,分子靶标,抗菌膜。
Current Medicinal Chemistry
Title:Benzothiazole-based Compounds in Antibacterial Drug Discovery
Volume: 25 Issue: 38
关键词: 苯并噻唑,抗菌,细菌耐药性,分子靶标,抗菌膜。
摘要: Numerous compounds with a benzothiazole scaffold that have been described in the literature show promising activities against several Gram-positive and Gramnegative bacteria, and also against Mycobacterium tuberculosis. Benzothiazole-based antibacterial compounds bind to different biological targets in bacterial cells and have been shown to be inhibitors of enzymes that are important for essential processes in the bacterial cells, such as cell-wall synthesis, cell division, and DNA replication, or are important for different biosynthetic pathways of essential compounds in bacterial cells, such as the biosynthesis of histidine and biotin. This review focuses on the antibacterial potential of benzothiazole-based compounds, in terms of their specific interactions with targets in bacterial cells. We assess the importance of the benzothiazole scaffold in the discovery of new antibacterial compounds, the potential of benzothiazole-based compounds against resistant bacterial strains, optimization of their antibacterial activity, and the future perspectives of benzothiazole-based antibacterials.
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Cite this article as:
Benzothiazole-based Compounds in Antibacterial Drug Discovery, Current Medicinal Chemistry 2018; 25 (38) . https://dx.doi.org/10.2174/0929867324666171009103327
DOI https://dx.doi.org/10.2174/0929867324666171009103327 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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