Abstract
Background: Alkaloids are a diverse group of naturally occurring secondary metabolites which exhibit various pharmacological properties. They have been synthesized via various synthetic routes in order to study their medicinal efficacy and structure activity relationships.
Methodology: Keeping in view the pharmaceutical significance of this class of compounds, the present review has been written with a focus on the synthetic approaches used for efficient construction of isoquinoline scaffolds in natural alkaloids including crispine A, emetine, erythrocarine, jamatine, annosqualine, morphine, lemonomycin, papaverine, berberine, and codeine.
Conclusion: The main goal behind the compilation of these schemes is to inspire organic chemists and help reinvigorate the development of novel strategies for the synthesis of isoquinoline alkaloids and their derivatives in the future.
Keywords: Biologically active natural products, tetrahydroisoquinolines, morphine, Bischler Napieralski Reaction, Pictet-Spengler Reaction, natural alkaloids.
Graphical Abstract
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
Related Books
Advances in Organic Synthesis
The Synthetic Methods, Structures, and Properties of the Ca-C σ Bond Organocalcium Containing Compounds
Advances in Organic Synthesis
Chemistry of Bipyrazoles: Synthesis and Applications
Advances in Organic Synthesis
Advanced Nanocatalysis for Organic Synthesis and Electroanalysis
Advances in Organic Synthesis
Advances in Organic Synthesis
69
2