摘要
背景:为实体器官移植受者提供的长期免疫抑制治疗不可避免地导致显着抑制免疫防御;这导致频繁的皮肤感染和恶性肿瘤,这是移植患者的发病率和死亡率的重要原因。与一般人群相比,实体器官移植受者皮肤癌的发病率和风险升高,基底细胞癌风险增加10倍,鳞状细胞癌风险增加50-100倍。免疫抑制药物的时间表影响皮肤恶性肿瘤的类型和时间,但内源性和外源性危险因素也起到关键作用。 方法和结果:在这里,我们将回顾表皮癌化学预防的最新进展,以便为参与移植受者管理的临床医生提供有用的信息。包括在同行评议的期刊上发表的一百一十四篇论文。 结论:化学预防将是控制高危患者皮肤癌变的关键。
关键词: 化学预防,皮肤癌,实体器官移植,免疫抑制,烟酰胺,维甲酸。
Current Medicinal Chemistry
Title:Chemoprevention of Skin Carcinomas in High-Risk Transplant Recipients
Volume: 25 Issue: 6
关键词: 化学预防,皮肤癌,实体器官移植,免疫抑制,烟酰胺,维甲酸。
摘要: Background: Long-term immunosuppressive therapy, as provided to solid organ transplant recipients, inevitably results in a significant inhibition of immune defenses; this leads to frequent skin infections and malignancies, which represent an important cause of morbidity and mortality for transplanted patients. The incidence and risk of skin carcinomas are elevated in solid organ transplant recipients in comparison with the general population, with a 10-fold increased risk for basal cell carcinoma and a 50-100-fold for squamous cell carcinoma. The schedule of immunosuppressive drugs influences the type and timing of skin malignancies, but a crucial role is also played by endogenous and exogenous risk factors.
Methods & Results: Here, we will review the state-of-the-art in chemoprevention of epidermal carcinomas in order to provide useful information for clinicians involved in the management of transplant recipients. One-hundred and forteen paper, published on peerreviewed journals, has been included.
Conclusion: Chemoprevention would be key in controlling skin carcinogenesis in high-risk patients.
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Cite this article as:
Chemoprevention of Skin Carcinomas in High-Risk Transplant Recipients, Current Medicinal Chemistry 2018; 25 (6) . https://dx.doi.org/10.2174/0929867324666171003123056
DOI https://dx.doi.org/10.2174/0929867324666171003123056 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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