摘要
智能聚合物纳米凝胶具有合理设计的刺激响应药物递送和受控药物释放，作为用于可激活疗法的理想纳米平台已引起相当大的关注。另一方面，功能性无机纳米材料由于其独特的磁性或光学性质而被广泛用作医学成像剂。结合功能性无机纳米材料的刺激响应性聚合物纳米凝胶的构造继承了聚合物和无机纳米材料的优异性质，因此，所得的有机 - 无机混合纳米凝胶自然地表现出对成像和治疗的刺激响应性多功能性。在这篇综述中，我们总结了刺激响应有机 - 无机杂化纳米凝胶的最新进展。首先，我们讨论了迄今为止用于聚合纳米凝胶和无机纳米材料整合的物理和化学方法，然后我们展示了使用有机 - 无机杂化纳米凝胶的可激活治疗应用的典型实例。最后，简要讨论了现有的挑战和未来的方向。
关键词: 刺激响应，有机 - 无机纳米凝胶，无机纳米材料，治疗诊断学，乙二醇壳聚糖（GC）单体和活性氧物种（ROS）。
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