A Review on the Effects of Androgen Deprivation Therapy (ADT) on Bone Health Status in Men with Prostate Cancer

Title:A Review on the Effects of Androgen Deprivation Therapy (ADT) on Bone Health Status in Men with Prostate Cancer

Volume: 17 Issue: 4

Author(s): Nur-Vaizura Mohamad, Ima-Nirwana Soelaiman and Kok-Yong Chin*

Affiliation:

• Department of Pharmacology, Level 17, Preclinical Building, Universiti Kebangsaan Malaysia Medical Centre, Jalan Yaacob Latif, Bandar Tun Razak, 56000 Cheras, Kuala Lumpur,,Malaysia

Keywords: Prostate cancer, testosterone, androgen deprivation therapy, bone health, bone mineral density (BMD), radiotherapy.

Abstract: Background and Objective: Prostate cancer is the most prevalent non-cutaneous cancer in men, which causes significant mortality among the patients. Since prostate cancer cells are stimulated by androgen, effective androgen ablation in men is one of the essential strategies in the management of prostate cancer.

Discussion: Several treatment options are available for different stages of prostate cancer. Hormone therapy known as androgen deprivation therapy (ADT) is the first line treatment used to treat advanced prostate cancer. Chemical castration by gonadotropin-releasing hormone agonists suppresses lutenizing hormone production, which in turn inhibits the production of testosterone and dihydrotestosterone. This will prevent the growth of prostate cancer cells. However, ADT causes deleterious effects on bone health because the androgens are essential in preserving optimal bone health in men.

Conclusion: Various observational studies showed that long-term ADT for advanced or metastatic prostate cancer was associated with decreased bone mineral density, as well as altered body composition that might affect bone health. Considering the potential impact of osteoporotic fracture, interventions to mitigate these skeletal adverse effects should be considered by physicians when initiating ADT on their patients.

Cite this article as:

Mohamad Nur-Vaizura, Soelaiman Ima-Nirwana and Chin Kok-Yong*, A Review on the Effects of Androgen Deprivation Therapy (ADT) on Bone Health Status in Men with Prostate Cancer, Endocrine, Metabolic & Immune Disorders - Drug Targets 2017; 17 (4) . https://dx.doi.org/10.2174/1871530317666170919112757

DOI https://dx.doi.org/10.2174/1871530317666170919112757	Print ISSN 1871-5303
Publisher Name Bentham Science Publisher	Online ISSN 2212-3873