Abstract
Major aspects of the synthetic utility of 1,3-diketones are reviewed with special emphasis being placed on the regioselectivity of the transformations. The unsymmetrical 1,3-diketone moiety may contain up to five nucleophilic and two electrophilic centers that may only slightly differ in reactivity; therefore, it seems almost impossible to carry out chemical transformations with substrate selectively at only one specific center. However, in many cases it is possible, and in the present review answers to this question as well as many other useful synthetic applications of 1,3-diketones for the construction of carbocycles and heterocycles, and their modern implication in enantioselective, combinatorial, solid phase, and multistep organic syntheses are summarized.
Keywords: 1,3-Diketones, Synthetic Applications, regioselectivity, chemical transformations
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
Related Books
Advances in Organic Synthesis
The Synthetic Methods, Structures, and Properties of the Ca-C σ Bond Organocalcium Containing Compounds
Advances in Organic Synthesis
Chemistry of Bipyrazoles: Synthesis and Applications
Advances in Organic Synthesis
Advanced Nanocatalysis for Organic Synthesis and Electroanalysis
Advances in Organic Synthesis
Advances in Organic Synthesis
18