XBP-1, a Cellular Target for the Development of Novel Anti-viral Strategies

Title:XBP-1, a Cellular Target for the Development of Novel Anti-viral Strategies

Volume: 19 Issue: 2

Author(s): Han Kee Ong, Benjamin P.C. Soo, Kai Ling Chu and Sheng-Hao Chao*

Affiliation:

• Expression Engineering, Bioprocessing Technology Institute, Agency for Science, Technology and Research (A*STAR), Singapore 138668,Singapore

Keywords: XBP-1, unfolded protein response, viral replication, anti-viral strategy, endoplasmic reticulum, secretory proteins.

Abstract: X-box binding protein 1 (XBP-1) is a key regulator of the unfolded protein response (UPR), which is activated in response to endoplasmic reticulum (ER) stress. Cells contain two protein isoforms of XBP-1, the active isoform (XBP-1S) and the inactive isoform (XBP-1U). Induction of UPR leads to the generation of XBP-1S while XBP-1U is dominant in ER stress-free cells. XBP-1S is a transcriptional activator and regulates the expression of a subset of UPR genes. Importantly, recent studies have demonstrated the essential role of XBP-1S in various human diseases, such as viral infections. Many viruses have evolved to manipulate UPR/XBP-1 of the infected cells to promote viral survival and replication. In this review, we will summarize the current findings on the involvement of XBP-1 in viral infection/ replication and discuss the potential anti-viral strategies by targeting XBP-1.

Cite this article as:

Ong Kee Han , Soo P.C. Benjamin, Chu Ling Kai and Chao Sheng-Hao *, XBP-1, a Cellular Target for the Development of Novel Anti-viral Strategies, Current Protein & Peptide Science 2018; 19 (2) . https://dx.doi.org/10.2174/1389203718666170911144812

DOI https://dx.doi.org/10.2174/1389203718666170911144812	Print ISSN 1389-2037
Publisher Name Bentham Science Publisher	Online ISSN 1875-5550