Design and Development of Integrase Inhibitors as Anti-HIV Agents

Title: Design and Development of Integrase Inhibitors as Anti-HIV Agents

Volume: 10 Issue: 18

Author(s): S. P. Gupta and A. N. Nagappa

Affiliation:

Keywords: integrase inhibitors, hiv-1 integrase, oligonucleotides, double-stranded

Abstract: A review is presented on different categories of compounds that have been studied for the inhibition of the HIV-1 integrase to develop anti-HIV agents. These compounds are: oligonucleotides (double-stranded, triplex, and G-quartet), curcumin analogues, polyhydroxylated aromatic compounds, diketo acids, caffeoyl- and galloyl - based compounds, hydrazides and amides, tetracyclines, and depsides and depsidones. For all these compounds, the important structural features essential for the inhibition of the integrase are pointed out.

Cite this article as:

Gupta P. S. and Nagappa N. A., Design and Development of Integrase Inhibitors as Anti-HIV Agents, Current Medicinal Chemistry 2003; 10 (18) . https://dx.doi.org/10.2174/0929867033456972