摘要
背景:精神病是阿尔茨海默病(AD)中常见的现象。 APOEε4等位基因是AD发病的最强遗传风险因子,但其与精神病的关系仍不清楚。 目的:我们调查了精神病,细分为妄想和幻觉之间的关联,以及APOEε4等位基因对认知和功能结局的影响。其次,我们调查了APOEε4,路易小体和精神病之间的关系。 方法:使用来自国家阿尔茨海默病协调中心(NACC)的数据。根据NIA-AA Reagan确诊的100例AD患者被纳入分析。全球认知评估使用简易精神状态检查(MMSE)和功能状态评估使用功能活动问卷(FAQ)。使用神经精神量表问卷(NPI-Q)确定精神病状态。因素设计被用来评估精神病和APOEε4的影响,以及它们的相互作用。 结果:精神病和APOEε4的存在均与MMSE评分较低相关,而只有精神病与较高FAQ分数相关。此外,幻觉患者的MMSE和常见问题评分均低于仅有妄想的患者。精神病和APOEε4在MMSE评分上存在显着的相互作用效应,APOEε4对仅有幻觉的精神病患者有负面影响。 APOEε4与路易体病理学的存在呈正相关,并且两者在精神病患者中更为普遍,其与幻觉之间的关联性更强。 结论:AD中的精神病与认知功能障碍和功能障碍相关。与只有妄想的患者相比,幻觉患者(无论是否有妄想)的赤字更大。 APOEε4等位基因与认知能力较差相关,特别是对仅有幻觉的精神病患者。 APOEε4可能通过路易体的发育介导了幻觉表型的认知障碍。我们的研究结果支持应该分别评估精神病的亚型。
关键词: 幻觉,幻觉,精神病,路易体,阿尔茨海默病,APOE,认知,神经病理学
Current Alzheimer Research
Title:Association Between Psychosis Phenotype and APOE Genotype on the Clinical Profiles of Alzheimer's Disease
Volume: 15 Issue: 2
关键词: 幻觉,幻觉,精神病,路易体,阿尔茨海默病,APOE,认知,神经病理学
摘要: Background: Psychosis is a common phenomenon in Alzheimer's disease (AD). The APOE ε4 allele is the strongest genetic risk factor for the development of AD, but its association with psychosis remains unclear.
Objective: We investigated the associations between psychosis, subdivided into delusions and hallucinations, as well as APOE ε4 allele on cognitive and functional outcomes. Secondarily, we investigated the associations between APOE ε4, Lewy bodies, and psychosis.
Methods: Data from the National Alzheimer's Coordinating Center (NACC) were used. Nine hundred patients with a confirmed diagnosis of AD based on the NIA-AA Reagan were included in the analysis. Global cognition was assessed using the Mini-Mental State Exam (MMSE) and functional status was assessed using the Functional Activities Questionnaire (FAQ). Psychosis status was determined using the Neuropsychiatric Inventory Questionnaire (NPI-Q). Factorial design was used to assess the effects of psychosis and APOE ε4, as well as their interaction.
Results: Psychosis and the presence of APOE ε4 were both associated with lower MMSE scores, while only psychosis was associated with higher FAQ scores. Furthermore, patients with hallucinations had lower MMSE and higher FAQ scores than patients with only delusions. There was a significant interaction effect between psychosis and APOE ε4 on MMSE scores, with APOE ε4 negatively affecting patients with hallucinations-only psychosis. APOE ε4 was positively associated with the presence of Lewy body pathology, and both were found to be more prevalent in psychotic patients, with a stronger association with hallucinations.
Conclusion: Psychosis in AD was associated with greater cognitive and functional impairments. Patients with hallucinations-with or without delusions-conferred even greater deficits compared to patients with only delusions. The APOE ε4 allele was associated with worse cognition, especially for patients with hallucination-only psychosis. APOE ε4 may mediate cognitive impairment in the hallucinations phenotype through the development of Lewy bodies. Our findings support that subtypes of psychosis should be evaluated separately.
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Cite this article as:
Association Between Psychosis Phenotype and APOE Genotype on the Clinical Profiles of Alzheimer's Disease, Current Alzheimer Research 2018; 15 (2) . https://dx.doi.org/10.2174/1567205014666170829114346
DOI https://dx.doi.org/10.2174/1567205014666170829114346 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
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