轻度认知功能障碍和阿尔茨海默病词汇表达的语音标记

Title:Voice Markers of Lexical Access in Mild Cognitive Impairment and Alzheimer's Disease

Volume: 15 Issue: 2

关键词: 阿尔茨海默病，轻度认知障碍，失语症，声学分析，言语，记忆。

摘要: Background: Recent studies have identified the correlation between dementia and certain vocal features, such as voice and speech changes. Vocal features may act as early markers of Alzheimer's disease (AD). Despite being present in non-pathological senescence and Mild Cognitive Impairment, especially in its amnesic subtype (aMCI), these voice- and speech-related symptoms are the first signs of AD. The purpose of this study is to verify whether these signs are related to deficits in lexical access, which appear early in AD.

Method: Anomic deficits in persons with MCI and AD are assessed through tests on verbal memory, denomination by confrontation, and verbal fluency. In addition, an acoustic analysis of speech is conducted in a reading task to identify the acoustic parameters associated with the groups analyzed, and their relation to the degree of anomic impairment observed in each one of them.

Results and Conclusions: The results show a direct relationship between the different acoustic parameters present in AD and the verbal fluency tests results.

Cite this article as:

Voice Markers of Lexical Access in Mild Cognitive Impairment and Alzheimer's Disease, Current Alzheimer Research 2018; 15 (2) . https://dx.doi.org/10.2174/1567205014666170829112439