摘要
背景:感觉运动整合机制可能受到许多因素的影响,其中包括神经肌肉疾病。帕金森病(PD)以众所周知的运动症状为特征,其中最近已包括运动语言障碍。声学反射(ASR)及其调制(分别为前脉冲抑制和预脉冲,PPI和PPF)的测量是评估感觉运动功能的简单和可量化的工具。然而,PPI和PPF的措施是否与PD患者的运动语言障碍相关尚不清楚。 方法:共有88名受试者参加了本研究,52名被诊断为PD患者和36名对照受试者。在获得书面知情同意书后,参与者在几个刺激间隔内用PPI进行评估,并使用SRH-Lab系统(San Diego,CA)在1000ms对PPF进行评估。在组之间分析ASR振幅和潜伏期变化的百分比。语音记录是用专业记录器给予对象的特定文本的登记,并分析语音的时间模式。 结果:在本研究中进行的统计分析显示与对照组相比,PD受试者中PPI和PPF的差异。另外,在与对照对象相关的PD受试者中观察到语音异常的判别性参数,所述对象显示发声时间,元音脉冲,断裂,断裂和语音语音周期的减少。 结论:PD在感觉运动过滤机制和语言障碍方面存在障碍,这些改变之间有一定的关系。在PD受试者中,PPI和PPF之间的相关性改变了语音,这有助于理解两个过程中神经生理学改变的基础。总的来说,简单和非侵入性的测试,如PPI,PPF和语音分析可能有助于确定PD的早期阶段。
关键词: 发音系统,基频,感觉运动门控,言语测量,神经肌肉疾病,帕金森病。
Current Alzheimer Research
Title:Relations between Sensorimotor Integration and Speech Disorders in Parkinson's Disease
Volume: 15 Issue: 2
关键词: 发音系统,基频,感觉运动门控,言语测量,神经肌肉疾病,帕金森病。
摘要: Background: Sensorimotor integration mechanisms can be affected by many factors, among which are those involving neuromuscular disorders. Parkinson's disease (PD) is characterized by well-known motor symptoms, among which lately have been included motor speech deficits. Measurement of the acoustic startle reflex (ASR) and its modulations (prepulse inhibition and prepulse facilitation, PPI and PPF respectively) represent a simple and quantifiable tool to assess sensorimotor function. However, it remains unknown whether measures of the PPI and PPF are associated with motor speech deficits in PD.
Methods: A total of 88 subjects participated in this study, 52 diagnosed with PD and 36 control subjects. After obtaining written informed consent, participants were assessed with PPI at several interstimulus intervals, and PPF at 1000 ms using the SRH-Lab system (San Diego, CA). Percentage of change in the amplitude and latency of the ASR was analyzed between groups. Voice recordings were register of a specific text given to the subjects with a professional recorder and temporal patterns of speech were analyzed.
Results: Statistical analysis conducted in this study showed differences in PPI and PPF in subjects with PD compared to controls. In addition, discriminative parameters of voice abnormalities were observed in PD subjects related to control subjects showing a reduction in phonation time, vowel pulses, breaks, breakage and voice speech periods.
Conclusions: PD presents a disruption in sensorimotor filter mechanisms and speech disorders, and there is a relationship between these alterations. The correlation between the PPI and PPF with an alteration of the voice in PD subjects contributes toward understanding mechanism underlying the neurophysiological alterations in both processes. Overall, easy and non-invasive tests such as PPI, PPF together with voice analysis may be useful to identify early stages of PD.
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Cite this article as:
Relations between Sensorimotor Integration and Speech Disorders in Parkinson's Disease, Current Alzheimer Research 2018; 15 (2) . https://dx.doi.org/10.2174/1567205014666170829103019
DOI https://dx.doi.org/10.2174/1567205014666170829103019 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
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