Novel Azole-Functionalited Flouroquinolone Hybrids: Design, Conventional and Microwave Irradiated Synthesis, Evaluation as Antibacterial and Antioxidant Agents

Title:Novel Azole-Functionalited Flouroquinolone Hybrids: Design, Conventional and Microwave Irradiated Synthesis, Evaluation as Antibacterial and Antioxidant Agents

Volume: 15 Issue: 1

Author(s): Meltem Mentese, Neslihan Demirbas*, Arif Mermer, Serpil Demirci, Ahmet Demirbas and Faik Ahmet Ayaz

Affiliation:

• Department of Chemistry, Karadeniz Technical University, 61080 Trabzon,Turkey

Keywords: Fluoroquinolone, 1, 2, 4-triazole, 1, 3, 4-oxadiazole, piperazine, antibacterial activity, antioxidant activity, microwave.

Abstract: Background: The synthesis of new hybrid molecules consisting of several heterocyclic pharmacophores namely fluoroquinolone, 1,2,4-triazole, 1,3,4-oxadiazole and piperazine was carried out by conventional and successfully optimized microwave mediated techniques.

Methods: The structures of new compounds were confirmed using spectroscopic techniques. These compounds were screened for their antibacterial activity against E. coli, P. aeruginosa, Y. pseudotuberculosis, S. aureus, E. faecalis, B. cereus and M. smegmatis.

Results and Conclusion: Fourteen of these hybrids exhibited excellent antibacterial activities on the test microorganisms when compared with ampicillin with the mic values varying between 0.03- 0.25 µg/mL.

Cite this article as:

Mentese Meltem , Demirbas Neslihan*, Mermer Arif , Demirci Serpil , Demirbas Ahmet and Ayaz Ahmet Faik , Novel Azole-Functionalited Flouroquinolone Hybrids: Design, Conventional and Microwave Irradiated Synthesis, Evaluation as Antibacterial and Antioxidant Agents, Letters in Drug Design & Discovery 2018; 15 (1) . https://dx.doi.org/10.2174/1570180814666170823163540