摘要
光动力疗法(PDT)是一种治疗肿瘤和非肿瘤疾病的替代方法。这是一种微创治疗,涉及到相互作用。一种无毒的光敏剂(PS),光和分子氧产生活性氧(ROS),导致不必要的细胞和组织的破坏。新事物的发现与发展PSS性能优化是获得理想疗效的关键。本文综述了PDT的光化学和光生物机制,并概述了最近的研究进展。研究发现和开发天然产品及其衍生物作为光治疗药物。并对PDT在临床应用中的潜在局限性和前景进行了展望。讨论和讨论。
关键词: 光动力疗法,光敏剂,天然产物,药物发现,抗癌,活性氧。
Current Medicinal Chemistry
Title:Discovery and Development of Natural Products and their Derivatives as Photosensitizers for Photodynamic Therapy
Volume: 25 Issue: 7
关键词: 光动力疗法,光敏剂,天然产物,药物发现,抗癌,活性氧。
摘要: Photodynamic therapy (PDT) has been developed as an alternative modality for the management of neoplastic and nonneoplastic diseases. It is a minimally invasive treatment that involves the interaction of a non-toxic photosensitizer (PS), light and molecular oxygen to generate reactive oxygen species (ROS), resulting in the destruction of unwanted cells and tissues. Discovery and development of new PSs with optimized properties are much crucial for achieving a desirable therapeutic efficacy. This review describes the photochemical and photobiological mechanisms of PDT, and outlines the recent progress in discovery and development of natural products and their derivatives as phototherapeutic drugs. The potential limitations and future perspectives of PDT in clinical application are also presented and discussed.
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Cite this article as:
Discovery and Development of Natural Products and their Derivatives as Photosensitizers for Photodynamic Therapy, Current Medicinal Chemistry 2018; 25 (7) . https://dx.doi.org/10.2174/0929867324666170823143137
DOI https://dx.doi.org/10.2174/0929867324666170823143137 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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