摘要
光动力疗法(PDT)是一种治疗肿瘤和非肿瘤疾病的替代方法。这是一种微创治疗,涉及到相互作用。一种无毒的光敏剂(PS),光和分子氧产生活性氧(ROS),导致不必要的细胞和组织的破坏。新事物的发现与发展PSS性能优化是获得理想疗效的关键。本文综述了PDT的光化学和光生物机制,并概述了最近的研究进展。研究发现和开发天然产品及其衍生物作为光治疗药物。并对PDT在临床应用中的潜在局限性和前景进行了展望。讨论和讨论。
关键词: 光动力疗法,光敏剂,天然产物,药物发现,抗癌,活性氧。
Current Medicinal Chemistry
Title:Discovery and Development of Natural Products and their Derivatives as Photosensitizers for Photodynamic Therapy
Volume: 25 Issue: 7
关键词: 光动力疗法,光敏剂,天然产物,药物发现,抗癌,活性氧。
摘要: Photodynamic therapy (PDT) has been developed as an alternative modality for the management of neoplastic and nonneoplastic diseases. It is a minimally invasive treatment that involves the interaction of a non-toxic photosensitizer (PS), light and molecular oxygen to generate reactive oxygen species (ROS), resulting in the destruction of unwanted cells and tissues. Discovery and development of new PSs with optimized properties are much crucial for achieving a desirable therapeutic efficacy. This review describes the photochemical and photobiological mechanisms of PDT, and outlines the recent progress in discovery and development of natural products and their derivatives as phototherapeutic drugs. The potential limitations and future perspectives of PDT in clinical application are also presented and discussed.
Export Options
About this article
Cite this article as:
Discovery and Development of Natural Products and their Derivatives as Photosensitizers for Photodynamic Therapy, Current Medicinal Chemistry 2018; 25 (7) . https://dx.doi.org/10.2174/0929867324666170823143137
DOI https://dx.doi.org/10.2174/0929867324666170823143137 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Cystic Hygroma with Multiple Benign Bone Lymphangiomas in an Adult Patient: A Rare Entity in the Differential Diagnosis of Multiple Osseous Lesions in Oncology Practice
Current Medical Imaging P-gp Transporter and its Role in Neurodegenerative Diseases
Current Topics in Medicinal Chemistry Medicinal Compound Celastrol As a Potential Clinical Anticancer Drug: Lessons Learned From Preclinical Studies
Clinical Cancer Drugs Expression of Estrogen-Regulated Genes During Development in the Mouse Uterus Exposed to Diethylstilbestrol Neonatally
Current Pharmaceutical Design The Epidemiology and Health Effects of Tobacco Use
Current Pediatric Reviews Current Management of Neonatal Soft-tissue Sarcomas and Benign Tumors with Local Aggressiveness
Current Pediatric Reviews Changes in the Expression of the Alzheimers Disease-Associated Presenilin Gene in Drosophila Heart Leads to Cardiac Dysfunction
Current Alzheimer Research Transcatheter Embolization Therapy in Liver Cancer
Recent Patents on Medical Imaging Clinical Outcomes of the Transplantation of Stem Cells from Various Human Tissue Sources in the Management of Liver Cirrhosis: A Systematic Review and Meta-Analysis
Current Stem Cell Research & Therapy Targeting Microtubules to Inhibit Angiogenesis and Disrupt Tumour Vasculature:Implications for Cancer Treatment
Current Cancer Drug Targets Microfluidic Devices for Cell, Tissue and Embryo Culture
Recent Patents on Regenerative Medicine Antithrombotic Treatment Management in Patients with Intracerebral Hemorrhage: Reversal and Restart
Current Pharmaceutical Design Generation of Human Cardiomyocytes for Cardiac Regenerative Therapies: Differentiation and Direct Reprogramming
Current Pharmaceutical Design TGF-β Receptor Signaling Pathways in Angiogenesis; Emerging Targets for Anti-Angiogenesis Therapy
Current Pharmaceutical Biotechnology p53 Gene Family: Structural, Functional and Evolutionary Features
Current Genomics Factors Modulating Chondrogenesis and Mechano-Inductive Systems for Cartilage Tissue Engineering from Mesenchymal Stem Cells: A Review
Current Tissue Engineering (Discontinued) Colchicine: An Old Wine in a New Bottle?
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Use of Contrast Echocardiography in Intensive Care and at the Emergency Room
Current Cardiology Reviews Immunoproteasome in Cancer and Neuropathologies: A New Therapeutic Target?
Current Pharmaceutical Design Impact of Pulmonary Vascular Resistances in Heart Transplantation for Congenital Heart Disease
Current Cardiology Reviews