Abstract
Introduction: Phylogenetic relationships between different lineages of Trypanosoma cruzi, the agent of Chagas disease, have been controversial for several years. However, recent phylogenetic and phylogenomic analyses clarified the nuclear relationships among such lineages. However, incongruence between nuclear and kinetoplast DNA phylogenies has emerged as a new challenge. This incongruence implies several events of mitochondrial introgression at evolutionary level. However, the mechanism that gave origin to introgressed lineages is unknown. Here, I will review and discuss how maxicircles of the kinetoplast were horizontally and vertically transferred between different lineages of T. cruzi.
Conclusion: Finally, I will discuss what we know - and what we don't - about the kDNA transference and inheritance in the context of sexual reproduction in this parasite.
Keywords: Trypanosoma cruzi, DTU, Evolution, Phylogeny, Hybridization, Kinetoplast, Mitochondrial introgression.
Graphical Abstract
Current Genomics
Title:Introgression of the Kinetoplast DNA: An Unusual Evolutionary Journey in Trypanosoma cruzi
Volume: 19 Issue: 2
Author(s): Nicolas Tomasini*
Affiliation:
- Instituto de Patologia Experimental, Facultad de Ciencias de la Salud, Universidad Nacional de Salta, CONICET, Salta,Argentina
Keywords: Trypanosoma cruzi, DTU, Evolution, Phylogeny, Hybridization, Kinetoplast, Mitochondrial introgression.
Abstract: Introduction: Phylogenetic relationships between different lineages of Trypanosoma cruzi, the agent of Chagas disease, have been controversial for several years. However, recent phylogenetic and phylogenomic analyses clarified the nuclear relationships among such lineages. However, incongruence between nuclear and kinetoplast DNA phylogenies has emerged as a new challenge. This incongruence implies several events of mitochondrial introgression at evolutionary level. However, the mechanism that gave origin to introgressed lineages is unknown. Here, I will review and discuss how maxicircles of the kinetoplast were horizontally and vertically transferred between different lineages of T. cruzi.
Conclusion: Finally, I will discuss what we know - and what we don't - about the kDNA transference and inheritance in the context of sexual reproduction in this parasite.
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Cite this article as:
Tomasini Nicolas *, Introgression of the Kinetoplast DNA: An Unusual Evolutionary Journey in Trypanosoma cruzi, Current Genomics 2018; 19 (2) . https://dx.doi.org/10.2174/1389202918666170815124832
DOI https://dx.doi.org/10.2174/1389202918666170815124832 |
Print ISSN 1389-2029 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5488 |
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