摘要
背景:开发有效的抗病毒药物已经付出了巨大的努力,但迄今为止,许多病毒感染仍然缺乏有效的抗病毒治疗。天然产物抗病毒的相关研究近年来有所提高。具有结构多样性和复杂性的天然化合物为寻找新的抗病毒剂提供了很好的机会。特别是酚酸由于其强大的抗病毒能力和独特的机制而引起了相当的关注。这次审查的目的是报告新的发现和更新有关的抗病毒酚酸。 方法:搜索天然酚酸的相关参考文献。抗病毒酚酸根据其结构特性和抗病毒类型进行分类。同时总结了酚酸及其衍生物的抗病毒特性和构效关系。 结果:发现天然酚酸及其衍生物对人类免疫缺陷病毒,丙型肝炎病毒,乙型肝炎病毒,单纯疱疹病毒,流感病毒,呼吸道合胞病毒等多种病毒具有较强的抑制作用。具体而言,咖啡酸/没食子酸及其衍生物通过多种作用方式表现出优异的抗病毒性。 结论:天然来源的酚酸尤其是咖啡酸/没食子酸及其衍生物可能被认为是新型的有希望的抗病毒药物。另外,几乎没有任何这些化合物在临床实践中被用作抗病毒治疗。因此,这些具有不同骨架和机制的酚酸为我们寻找新的抗病毒药物提供了极好的资源。
关键词: 天然产物,酚酸,病毒感染,结构性质,抗病毒机制,结构活性关系
Current Medicinal Chemistry
Title:Structure Properties and Mechanisms of Action of Naturally Originated Phenolic Acids and Their Derivatives against Human Viral Infections
Volume: 24 Issue: 38
关键词: 天然产物,酚酸,病毒感染,结构性质,抗病毒机制,结构活性关系
摘要: Background: A great effort has been made to develop efficacious antiviral drugs, but many viral infections are still lack of efficient antiviral therapies so far. The related exploration of natural products to fight viruses has been raised in recent years. Natural compounds with structural diversity and complexity offer a great chance to find new antiviral agents. Particularly, phenolic acids have attracted considerable attention owing to their potent antiviral abilities and unique mechanisms. The aim of this review is to report new discoveries and updates pertaining to antiviral phenolic acids.
Methods: The relevant references on natural phenolic acids were searched. The antiviral phenolic acids were classified according to their structural properties and antiviral types. Meanwhile, the antiviral characteristics and structure-activity relationships of phenolic acids and their derivatives were summarized.
Results: The review finds that natural phenolic acids and their derivatives possessed potent inhibitory effects on multiple virus in humans such as human immunodeficiency virus, hepatitis C virus, hepatitis B virus, herpes simplex virus, influenza virus and respiratory syncytial virus. In particular, caffeic acid/gallic acid and their derivatives exhibited outstanding antiviral properties by a variety of modes of action.
Conclusion: Naturally derived phenolic acids especially caffeic acid/gallic acid and their derivatives may be regarded as novel promising antiviral leads or candidates. Additionly, scarcely any of these compounds has been used as antiviral treatment in clinical practice. Therefore, these phenolic acids with diverse skeletons and mechanisms provide us an excellent resource for finding novel antiviral drugs.
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Cite this article as:
Structure Properties and Mechanisms of Action of Naturally Originated Phenolic Acids and Their Derivatives against Human Viral Infections, Current Medicinal Chemistry 2017; 24 (38) . https://dx.doi.org/10.2174/0929867324666170815102917
DOI https://dx.doi.org/10.2174/0929867324666170815102917 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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