摘要
背景:天然酚类化合物是次生植物代谢产物,可分为几类,具有酚羟基的共同结构特征。酚类化合物的生物活性通常通过异戊烯基和香叶基的异戊烯基化修饰和增强;较高的萜类链很少见。异戊二烯连接和修饰的类型影响它们的生物活性。 目的:本综述总结了异戊烯酚和其一些潜在来源的信息,并概述了它们在体外和体内的抗炎潜力。 方法:使用SciFinder和关键词异戊二烯,苯酚和炎症进行文献检索。对于单个化合物,进行了额外的搜索以查找有关进一步活动和影响机制的信息。 结果:我们总结了异戊烯化酚类化合物在细胞或生化系统中对炎症相关细胞因子产生和释放的影响;它们对抑制环氧合酶和脂氧合酶的作用;对产生一氧化氮,抗自由基和抗氧化活性的影响;以及抑制嗜中性粒细胞,肥大细胞和巨噬细胞释放酶和介质的效果。关于异戊烯化酚类物质的抗炎潜力的信息通过回顾它们在动物模型中的作用得到进一步支持。 结论:对近400种异戊烯基苯酚进行了综述,以总结它们的抗炎作用。还使用体内测定法确认了几种异戊烯基苯酚的生物活性。一组天然异戊烯醇酚代表合成的灵感来源,并且异戊烯酚作为用于对抗炎症的各种药用植物的成分可能是它们的活性成分。
关键词: 花生四烯酸代谢,细胞因子,炎症,异戊烯酚化合物,活性氧,潜在的铅物质。
Current Medicinal Chemistry
Title:Anti-inflammatory Natural Prenylated Phenolic Compounds - Potential Lead Substances
Volume: 25 Issue: 10
关键词: 花生四烯酸代谢,细胞因子,炎症,异戊烯酚化合物,活性氧,潜在的铅物质。
摘要: Background: Natural phenolics are secondary plant metabolites, which can be divided into several categories with the common structural feature of phenolic hydroxyl. The biological activity of phenolics is often modified and enhanced by prenylation by prenyl and geranyl; higher terpenoid chains are rare. The type of prenyl connection and modification affects their biological activity.
Objective: This review summarizes information about prenylated phenols and some of their potential sources, and provides an overview of their anti-inflammatory potential in vitro and in vivo.
Method: The literature search was performed using SciFinder and keywords prenyl, phenol, and inflammation. For individual compounds, an additional search was performed to find information about further activities and mechanisms of effects.
Result: We summarized the effects of prenylated phenolics in vitro in cellular or biochemical systems on the production and release of inflammation-related cytokines; their effects on inhibition of cyclooxygenases and lipoxygenases; the effects on production of nitric oxide, antiradical and antioxidant activity; and the effect on the inhibition of the release of enzymes and mediators from neutrophils, mast cells and macrophages. The information about the antiphlogistic potential of prenylated phenolics is further supported by a review of their action in animal models.
Conclusion: Almost 400 prenylated phenols were reviewed to overview their antiinflammatory effect. The bioactivity of several prenylated phenols was confirmed also using in vivo assays. A pool of natural prenylated phenols represents a source of inspiration for synthesis, and prenylated phenols as components of various medicinal plants used to combat inflammation could be their active principles.
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Cite this article as:
Anti-inflammatory Natural Prenylated Phenolic Compounds - Potential Lead Substances, Current Medicinal Chemistry 2018; 25 (10) . https://dx.doi.org/10.2174/0929867324666170810161157
DOI https://dx.doi.org/10.2174/0929867324666170810161157 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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