Safety Profile of the Newest Antiepileptic Drugs: A Curated Literature Review

Title:Safety Profile of the Newest Antiepileptic Drugs: A Curated Literature Review

Volume: 23 Issue: 37

Author(s): Caterina Palleria, Giuseppe Cozza, Rajeshree Khengar, Vincenzo Libri and Giovambattista De Sarro*

Affiliation:

• Department of Science of Health, School of Medicine and Surgery, University of Catanzaro, Catanzaro,Italy

Keywords: Antiepileptic drugs, adverse drug reactions, tolerability, safety, interactions, clinical trials, metanalysis, pooled analysis.

Abstract: Background: Despite the introduction of new antiepileptic drugs (AEDs), the quality of life and therapeutic response for patients with epilepsy remain unsatisfactory. In addition, whilst several antiepileptic drugs (AEDs) have been approved and consequently marketed in recent years, little is known about their long-term safety and tolerability. Availability of the newest AEDs, characterized by improved pharmacokinetic profiles, has positively impacted the treatment approach for patients with partial seizures in clinical practice. However, the main cause of treatment failure is still poor patient compliance due to the occurrence of adverse drug reactions (ADRs) that lead to treatment withdrawal in about 25% of cases before achieving maximal efficacy, and is associated with increasing health care costs.

Methods: In this Review, we conducted an online database search using Medline, PubMed, Embase, and the Cochrane Online Library to review the available studies highlighting the clinical relevance of side effects, pharmacological interactions, safety and tolerability of the newest AEDs: Brivaracetam (BRV), Cannabidiol (CBD), Eslicarbazepine acetate (ESL), Lacosamide (LCM), and Perampanel (PER).

Results: The principal benefit of the newest AEDs, in addition to reduced frequency and seizure severity, is the low number and severity of ADRs reported compared to more historic drugs.

Conclusion: Early detection of ADRs could lead to an improvement in patients’ quality of life, therefore it is important to monitor ADRs and to adequately perform post marketing surveillance in the clinical practice setting.

Cite this article as:

Palleria Caterina, Cozza Giuseppe, Khengar Rajeshree, Libri Vincenzo and De Sarro Giovambattista*, Safety Profile of the Newest Antiepileptic Drugs: A Curated Literature Review, Current Pharmaceutical Design 2017; 23 (37) . https://dx.doi.org/10.2174/1381612823666170809115429

DOI https://dx.doi.org/10.2174/1381612823666170809115429	Print ISSN 1381-6128
Publisher Name Bentham Science Publisher	Online ISSN 1873-4286