摘要
背景:镉(Cd)是一种对人类健康特别危险的重金属,因为它是高度分散的,因此是一种无处不在的环境毒物。事实上,在一般人口中,接触的主要来源是食物,吸烟,吸入周围空气,饮用水,受污染的土壤或尘土。此外,职业暴露通常涉及采矿过程中的人类,吸入或制造镍镉电池,使用镉的电镀和涂料颜料。 方法:我们对有关镉的文献进行了结构性的检索。这种金属对许多器官的细胞是有害的,其中肾,睾丸和大脑在本文中将被考虑。 结果:Cd引起的毒性作用包括氧化应激,细胞死亡和炎症等多种特异性机制。由于没有针对预防或治疗与Cd暴露有关的发病率和死亡率的具体疗法,所以说明了治疗方法的现有技术。 结论:目前仍缺乏一种能够抵抗镉毒性的治疗方法,并要求开发新的治疗药物。
关键词: 镉,毒性,肾,脑,睾丸,治疗方法。
Current Medicinal Chemistry
Title:Cadmium, Organ Toxicity and Therapeutic Approaches: A Review on Brain, Kidney and Testis Damage
Volume: 24 Issue: 35
关键词: 镉,毒性,肾,脑,睾丸,治疗方法。
摘要: Background: Cadmium (Cd) is a heavy metal particularly hazardous for human health, as it is highly diffused and, therefore, a ubiquitous environmental toxicant. In fact, in the general population, the main sources of exposure are food, cigarette smoking, inhalation of ambient air, drinking water, contaminated soil or dust. Furthermore, an occupational exposure usually involves human during mining, fume inhalation or manufacturing nickel-cadmium battery, electroplating and paint pigments that utilize Cd.
Methods: We undertook a structured search in literature about Cd. This metal is noxious on the cells of many organs, among which the kidney, the testis and the brain will be considered in this review.
Results: The toxic effects induced by Cd include many specific mechanisms, such as the oxidative stress, cellular death and inflammation. As no specific therapy for the prevention or treatment of the morbidity and mortality associated with Cd exposure is available, the state of the art of the therapeutic approaches is illustrated.
Conclusion: Nowadays, a therapy able to counteract Cd toxicity is still lacking and the development of new therapeutic agents is requested.
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Cite this article as:
Cadmium, Organ Toxicity and Therapeutic Approaches: A Review on Brain, Kidney and Testis Damage, Current Medicinal Chemistry 2017; 24 (35) . https://dx.doi.org/10.2174/0929867324666170801101448
DOI https://dx.doi.org/10.2174/0929867324666170801101448 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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