摘要
背景:辅酶Q10(辅酶Q10)作为呼吸电子传递链中的电子载体,在线粒体氧化磷酸化过程中发挥着重要作用。辅酶Q10还可以通过保护脂质,蛋白质和氧化应激损伤的DNA而起到脂溶性抗氧化剂的作用。辅酶Q10缺乏症与许多人类疾病有关,其中辅酶Q10补充疗法已经有效地减缓或逆转病理学变化。氧化应激是视网膜变性过程中的主要促成因素。 方法:通过检索PubMed,利用CoQ10,CoQ10,氧化应激,CoQ10,视网膜变性等相关文献进行综述。对CoQ10的功能进行了总结,并将其用于治疗年龄相关性黄斑变性和青光眼。还讨论了CoQ10对其他视网膜疾病的治疗潜力。 结果:辅酶Q10已被应用于不同类型的神经变性。辅酶Q10在视网膜中可检测到并随着老化而下降。早期研究表明,辅酶Q10的治疗改善了年龄相关性黄斑变性患者的视功能。在青光眼模型中,辅酶Q10暴露保护了环境压力下的神经节细胞死亡;在青光眼患者中,CoQ10治疗显示出对内部视网膜功能和视觉皮层反应增强的有益作用。由于氧化应激在糖尿病性视网膜病和视网膜色素变性的发病中也起关键作用,所以CoQ10是这两种病症的治疗靶标。 结论:大量证据支持CoQ10在视网膜疾病中的作用,通过抑制活性氧的产生和保护神经视网膜细胞免受氧化损伤。
关键词: 辅酶Q10,氧化应激,视网膜,年龄相关性黄斑变性,青光眼,色素性视网膜炎,糖尿病性视网膜病,保护。
Current Medicinal Chemistry
Title:Therapeutic Potential of Co-enzyme Q10 in Retinal Diseases
Volume: 24 Issue: 39
关键词: 辅酶Q10,氧化应激,视网膜,年龄相关性黄斑变性,青光眼,色素性视网膜炎,糖尿病性视网膜病,保护。
摘要: Background: Coenzyme Q10 (CoQ10) plays a critical role in mitochondrial oxidative phosphorylation by serving as an electron carrier in the respiratory electron transport chain. CoQ10 also functions as a lipid-soluble antioxidant by protecting lipids, proteins and DNA damaged by oxidative stress. CoQ10 deficiency has been associated with a number of human diseases in which CoQ10 supplementation therapy has been effective in slowing or reversing pathological changes. Oxidative stress is a major contributory factor in the process of retinal degeneration.
Method: The related literature was reviewed through searching PubMed using keywords: CoQ10, CoQ10 and oxidative stress, CoQ10 and retinal degeneration. The functions of CoQ10 were summarized and its use in the treatment of age-related macular degeneration and glaucoma highlighted. The therapeutic potential of CoQ10 for other retinal diseases was also discussed.
Results: CoQ10 has been applied in different types of neurodegeneration. CoQ10 is detectable in retina and declines with ageing. Early studies showed treatment of CoQ10 improved visual function in patients with age-related macular degeneration. In glaucomatous models, CoQ10 exposure protected ganglion cell death from environmental stress; in glaucoma patients, CoQ10 treatment demonstrated beneficial effects on function of inner retina and enhancement of visual cortical response. Since oxidative stress also plays a critical role in the pathogenesis of diabetic retinopathy and retinitis pigmentosa, CoQ10 is a therapeutic target for both conditions.
Conclusion: A wide range of evidence supports a role of CoQ10 in retinal diseases through inhibiting production of reactive oxygen species and protecting neuroretinal cells from oxidative damage.
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Cite this article as:
Therapeutic Potential of Co-enzyme Q10 in Retinal Diseases, Current Medicinal Chemistry 2017; 24 (39) . https://dx.doi.org/10.2174/0929867324666170801100516
DOI https://dx.doi.org/10.2174/0929867324666170801100516 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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