摘要
估疾病的进展。用于检测和监测生物标记物的免疫传感器的发展目前是一个主要的研究领域,随着更多的标记物被发现,它们在疾病中的作用得到更好的理解,这一领域将继续增长。方法:报道近三年来在临床分析中应用的电化学免疫传感器的研究进展。结果:本文综述了电化学免疫传感器在癌症、心血管和神经系统疾病检测和监测方面的研究进展。介绍了免疫传感器的概况,以及目前用于检测上述疾病的发病和进展的生物标志物和生物传感系统。结论:电化学生物传感器正成为目前最广泛探索的科学领域之一。这是由于他们在临床诊断和生物过程监测方面的巨大潜力。在不久的将来,随着传感器技术、纳米材料技术和生物分子工程技术的发展,生物传感器将成为几个分析领域的有力工具。
关键词: 免疫学、生物医学、癌症、心脏病、autoimmune、Electro化学工业
Current Medicinal Chemistry
Title:Electrochemical Immunosensors for Disease Detection and Diagnosis
Volume: 25 Issue: 33
关键词: 免疫学、生物医学、癌症、心脏病、autoimmune、Electro化学工业
摘要: Background: The detection of biological molecules referred as biomarkers in biological fluids is fundamental in clinical analysis because it permits to discriminate between healthy and ill individuals and to evaluate the progress of a disease. The development of immunosensors for the detection and monitoring of biomarkers is currently a major area of research and, as more markers are discovered and their role in disease becomes better understood, this will continue to grow.
Methods: We report the research progresses of electrochemical immunosensor applied in clinical analysis that have been published in the last three years.
Results: The emphasis of this review is on the advances of the electrochemical immunosensors for detection and monitoring of cancerous, cardiovascular and neurological diseases. An immunosensor overview was presented as well as the biomarkers and biosensing systems currently used to detect the onset and monitor the progression of the mentioned diseases.
Conclusions: Electrochemical biosensors focusing on a vast repertoire of analytes are now becoming one of the most widely explored scientific fields. This is due to their enormous potential in clinical diagnosis and biological process monitoring.
In the near future, with the development of transducer technology, nano-sized material technology, and biomolecules engineering technology, biosensors should be powerful tools in several analytical areas.
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Cite this article as:
Electrochemical Immunosensors for Disease Detection and Diagnosis, Current Medicinal Chemistry 2018; 25 (33) . https://dx.doi.org/10.2174/0929867324666170727104429
DOI https://dx.doi.org/10.2174/0929867324666170727104429 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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