Synthesis and Biological Screening of N,N’-bis Disubstituted Adipic Acid Thioureas

Title:Synthesis and Biological Screening of N,N’-bis Disubstituted Adipic Acid Thioureas

Volume: 14 Issue: 6

Author(s): Aneela Maalik*, Sadia Hameed, Huma Aslam Bhatti, Abdur Rauf, Syed Majid Bukhari, Nighat Fatima, Hummera Rafique, Ehsan Ullah Mughal and Amara Mumtaz*

Affiliation:

• Department of Chemistry COMSATS University, 22060, Abbottabad Campus, Abbottabad,Pakistan

• Department of Chemistry COMSATS University, 22060, Abbottabad Campus, Abbottabad,Pakistan

Keywords: Antimicrobial, antioxident, cytotoxic, thioureas, adipic acid thiourea, potassium thiocynate.

Abstract: Background: Synthesis of substituted N’-aryl-N’-adipic acid thiourea (1-7) was, carried out adipic acid chlorides with potassium thiocynate in situ produced isocyanate followed by reflux with substituted anilines in dry acetone till the completion of reaction.

Methods: Structure elucidation of all the synthesized compounds was carried out by UV-Vis, FT-IR and 1HNMR analysis. All the synthesized compounds were evaluated for their biological screening by subjecting to antimicrobial and antioxidant activities.

Conclusion: In case of antibacterial screening most significant results were obtained by compound 7 having fluoro group at the para position with 16.5±1.0 zone of inhibition against methicilline resistant S. aureus (MRSA 09) while no activity was observed in case of antifungal activities. Compound 7 also showed significant antioxidant activities in DPPH assay with percent scavenging values of 63.51±.8.3.

Cite this article as:

Maalik Aneela *, Hameed Sadia , Bhatti Aslam Huma, Rauf Abdur , Bukhari Majid Syed , Fatima Nighat , Rafique Hummera , Mughal Ullah Ehsan and Mumtaz Amara *, Synthesis and Biological Screening of N,N’-bis Disubstituted Adipic Acid Thioureas, Current Pharmaceutical Analysis 2018; 14 (6) . https://dx.doi.org/10.2174/1573412913666170726122027