摘要
背景:免疫调节是重要的治疗策略之一。它包括通过称为免疫调节剂的多种物质来刺激和抑制免疫系统,所述物质被设计用于调节机体对抗不同病原体感染的免疫应答。这种物质的一个例子是tuftsin(TKPA)3(图(1))。本文包括了多年来描述的tuftsin衍生物,以及它们的生物活性和临床潜力。 方法:我们回顾了一个书目数据库收集所有关于tuftsin肽的重要信息。我们已经描绘了四肽本身及其衍生物活性的重要信息。类似物由于其抗肿瘤,抗炎,抗微生物和抗病毒活性而被分开。 结果:本文描述了八十六个文件。其中32人关注人体中tuftsin的活性。剩余的54个描述了肽类似物及其性质,包括关于疫苗中包含的基于tuftsin的肽的十一篇论文,代表tuftsin衍生物的抗癌活性的九篇论文,关于抗炎化合物的二十六篇以及描述抗肿瘤活性的五篇论文的tuftsin类似物。 结论:这次审查的结果证实了tuftsin及其衍生物的重要性。大多数这些物质显示出抗肿瘤,抗炎或抗菌活性。大量的化合物可用于疫苗。 Tuftsin也可用
关键词: Tuftsin,免疫调节剂,生物活性,Selank,tuftsin类似物,调节肽
Current Medicinal Chemistry
Title:Tuftsin – Properties and Analogs
Volume: 24 Issue: 34
关键词: Tuftsin,免疫调节剂,生物活性,Selank,tuftsin类似物,调节肽
摘要: Background: Immunomodulation is one of the significant therapeutic strategies. It includes both stimulation and suppression of the immune system by a variety of substances called immunomodulators, designed to regulate the immune response of the organism against infections of varying etiology. An example of such a substance is tuftsin (TKPA) 3 (Fig. (1)). In this paper were included tuftsin derivatives, which were described over the years, their together with biological activity and clinical potential.
Methods: We reviewed a bibliographic database to gather all the important information about the tuftsin peptide. We have delineated the significant information on the activity of the tetrapeptide itself and its derivatives. Analogs were divided because of their anti-tumor, anti-inflammatory, antimicrobial and anti-viral activity.
Results: This paper describes eighty-six documents. Thirty-two of them concern on activity of tuftsin in the human organism. The remaining fifty-four describe peptide analogues and their properties, including eleven papers about the tuftsin-based peptides contained in the vaccines, nine papers representing anticancer activity of the tuftsin derivatives, twenty-six about antiinflammatory compounds, and five papers describing the antitumor activity of the tuftsin analogs.
Conclusion: The findings of this review confirm the importance of the tuftsin and their derivatives. Most of these substances showed anti-tumor, anti-inflammatory or antibacterial activities. A large amount of the compounds may find use in vaccines. Tuftsin can also be used to prepare fusion proteins in the treatment of cancer and as carriers of many biologically active substances.
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Cite this article as:
Tuftsin – Properties and Analogs, Current Medicinal Chemistry 2017; 24 (34) . https://dx.doi.org/10.2174/0929867324666170725140826
DOI https://dx.doi.org/10.2174/0929867324666170725140826 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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