摘要
在过去的二十年中，植物中的药物蛋白质的生产从概念证明演变为若干生物技术公司采用的既定技术。这一进展尤其基于开展稳定遗传转化和转向瞬时表达的深入研究。由于其在产量和蛋白质生产速度方面的优势，瞬时表达平台成为领先的基于植物的制造技术。目前的瞬时表达方法依赖于农杆菌介导的表达载体递送到植物细胞中。近年来，在表达载体，宿主细胞工程的改进以及商业制造工艺的发展方面取得了很大进展。世界各地都有几种获得GMP认证的大规模生产设施，以利用农杆菌渗入法。通过瞬时表达产生的许多药物蛋白质目前正在临床开发中。通过产生针对埃博拉病毒以及流感疫苗的实验性ZMapp抗体，证明了瞬时表达平台在对新出现的大流行病的快速反应方面的巨大潜力。本综述主要关注生物制药蛋白生产的植物瞬时表达系统的当前设计，现状和未来前景。
关键词: 农杆菌介导的递送，药物蛋白，植物生产平台，瞬时表达，根癌农杆菌，工程，宿主细胞工程。
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