摘要
背景:地中海饮食对多种疾病的保护作用通常归因于某些食物的高消费,其特征是存在多酚等生物活性物质。炎症在诸如关节炎,过敏或神经退行性疾病等多种疾病的发病机理中起重要作用。膳食多酚构成一大类生物活性物质,对广泛的疾病具有潜在的有益作用。柑橘类水果和果汁是维生素C和类黄酮的丰富来源,可能对炎症反应产生影响。 目的:目的是证明黄酮类橙皮苷的潜在抗炎作用可能对多种病理学有治疗作用。方法:在本综述中,报道并讨论了关于橙皮苷抗炎作用的现有文献。此外,我们还讨论了橙皮苷的化学,生物利用度和提出的作用机制。 结果:橙皮苷是一种高浓度的柑橘类黄酮,具有多种生物学特性,主要是抗氧化和抗炎。已经进行了几项研究以使用细胞和动物模型以及很少的临床试验来评估橙皮苷作为抗炎剂的作用。橙皮苷治疗减少炎症介质并发挥显着的抗氧化作用。其抗炎作用的分子基础似乎是通过信号通路尤其是核因子κβ通路介导的。 结论:尽管橙皮苷具有抗炎作用,但具体的作用机制尚不完全清楚,需要进一步研究以阐明分子靶点。
关键词: 地中海饮食,炎症,细胞因子,多酚,黄酮。
Current Medicinal Chemistry
Title:Potential Anti-inflammatory Effects of Hesperidin from the Genus Citrus
Volume: 25 Issue: 37
关键词: 地中海饮食,炎症,细胞因子,多酚,黄酮。
摘要: Background: The benefits of the Mediterranean diet for protecting against many diseases are usually attributed to high consumption of certain foods, characterized by the presence of bioactive substances such as polyphenols. Inflammation plays an important role in the pathogenesis of numerous diseases such as arthritis, allergies or neurodegenerative disorders. Dietary polyphenols constitute a large family of bioactive substances with potential beneficial effects against a broad group of diseases. Citrus fruits and juices are a rich source of vitamin C and flavonoids, with a potential effect on the inflammatory response.
Objective: The aim was to evidence the potential anti-inflammatory effects of the flavonoids hesperidin for its possible therapeutic application against diverse pathologies.
Method: In the present review, available literature about the anti-inflammatory effects of hesperidin is reported and discussed. Moreover, we also discuss the chemistry, bioavailability and proposed mechanisms of action of hesperidin.
Results: Hesperidin is a flavonoid present in high concentration in citrus species and has numerous biological properties, principally antioxidant and anti-inflammatory. Several studies have been performed in order to evaluate the effects of hesperidin as anti-inflammatory agent using cellular and animal models and few clinical trials. Hesperidin treatment decreased inflammatory mediators and exerted significant antioxidant effects. The molecular basis for its anti-inflammatory effects seems to be mediated by signalling pathways especially the nuclear factor κβ pathway.
Conclusion: Although hesperidin evidenced anti-inflammatory effects, the specific mechanism of action is not completely known and additional studies are required for elucidation of the molecular targets.
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Cite this article as:
Potential Anti-inflammatory Effects of Hesperidin from the Genus Citrus, Current Medicinal Chemistry 2018; 25 (37) . https://dx.doi.org/10.2174/0929867324666170718104412
DOI https://dx.doi.org/10.2174/0929867324666170718104412 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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