Design, Synthesis and Antibacterial Evaluation of Compounds Based on New Benzoxepine-oxime-1,2,3-triazole Hybrid

Title:Design, Synthesis and Antibacterial Evaluation of Compounds Based on New Benzoxepine-oxime-1,2,3-triazole Hybrid

Volume: 18 Issue: 9

Author(s): Naveen Kuntala, Jhonsee Rani Telu, Venkanna Banothu, Sridhar Balasubramanian, Jaya Shree Anireddy and Sarbani Pal*

Affiliation:

• Department of Chemistry, MNR Degree & PG College, Kukatpally, Hyderabad-500072,India

Keywords: Antibacterial, benzoxepine, oxime, 1, 2, 3-triazole, hybrid, erythromycin.

Abstract: Background: A library of compounds related to the new benzoxepine-oxime-1,2,3-triazole hybrid was created as probable antibacterial agents. Their synthesis involved a Cu-catalyzed azidealkyne cycloaddition (CuAAC) as a key step to construct the desired 1,2,3-triazole ring. Thus the click reaction between the appropriate alkyne containing the benzoxepine-oxime framework with aryl azides afforded the target compounds in good yields.

Method: To assess their antibacterial properties all the synthesized compounds were tested using four bacterial strains consisting of one Gram-positive and three Gram-negative species.

Results & Conclusion: These compounds were generally found to be effective towards gram -ve species and one of them showed selective cytotoxicity against lung cancer cell line.

Cite this article as:

Kuntala Naveen, Telu Rani Jhonsee , Banothu Venkanna , Balasubramanian Sridhar , Anireddy Shree Jaya and Pal Sarbani *, Design, Synthesis and Antibacterial Evaluation of Compounds Based on New Benzoxepine-oxime-1,2,3-triazole Hybrid, Mini-Reviews in Medicinal Chemistry 2018; 18 (9) . https://dx.doi.org/10.2174/1389557517666170717123741