摘要
背景:从植物中分离的天然药物单体(NMMs)已经被认可在治疗包括癌症的不同人类疾病中的作用。许多NMM表现出有效的抗癌活性,可以作为药物或辅助剂来增强化疗和放疗的疗效。一些NMM如紫杉醇和喜树碱已经被广泛研究了数十年,由于其显着的疗效,如抑制癌细胞增殖和转移以及诱导细胞死亡和分化而被用作抗癌药物。 方法:在广泛回顾有关癌症NMM研究的论文后,我们根据NMM的化学结构将NMM分为六类。我们总结了这些NMM的抗癌活性和目前对其发挥功能的分子机制的知识。 结果和结论:来自植物的许多NMM可以有效地抑制对患者具有低或可耐受的毒性的癌细胞。一些NMM的抗癌活性已被很好地表征,并已被用作临床药物或佐剂;然而,大多数NMM的癌症抑制活性的机制仍然知之甚少。许多NMM可以用作初始结构支架来设计和开发针对癌症的新型治疗剂。本文综述了不同NMM介导的信号通路相关报道,为NMM的临床应用和新药开发提供理论依据
关键词: 关键词:抗癌活性,细胞凋亡,癌症治疗,细胞周期阻滞,天然药物单体,信号通路。
Current Medicinal Chemistry
Title:Therapeutic Application of Natural Medicine Monomers in Cancer Treatment
Volume: 24 Issue: 34
关键词: 关键词:抗癌活性,细胞凋亡,癌症治疗,细胞周期阻滞,天然药物单体,信号通路。
摘要: Background: Natural medicine monomers (NMMs) isolated from plants have been recognized for their roles in treating different human diseases including cancers. Many NMMs exhibit effective anti-cancer activities and can be used as drugs or adjuvant agents to enhance the efficacy of chemotherapy and radiotherapy. Some NMMs, such as paclitaxel and camptothecin, have been extensively studied for decades and are now used as anti-cancer medicines due to their remarkable curative effects, such as inhibiting cancer cell proliferation and metastasis, and inducing cell death and differentiation.
Methods: After extensively reviewing papers related to NMM studies in cancers, we grouped NMMs into six categories based on their chemical structures. We summarized the anti-cancer activities of these NMMs and current knowledge of molecular mechanisms for them to exert their functions.
Results and Conclusion: Many NMMs from plants can effectively inhibit cancer cells with low or tolerable toxicity to patients. Some NMMs have been well-characterized for their anti-cancer activities and have already been used as clinical drugs or adjuvant agents; however, the mechanisms underlying the cancer suppressive activities of most NMMs remain poorly understood. Many NMMs can be used as initial structural scaffolds to design and develop novel therapeutics against cancers. This review summarizes reports related to signaling pathways mediated by different NMMs and can provide a theoretical basis for clinical application and new drug development of NMMs.
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Cite this article as:
Therapeutic Application of Natural Medicine Monomers in Cancer Treatment, Current Medicinal Chemistry 2017; 24 (34) . https://dx.doi.org/10.2174/0929867324666170714101503
DOI https://dx.doi.org/10.2174/0929867324666170714101503 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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