Attenuation of Diabetes-induced Cardiac and Subcellular Defects by Sulphur-containing Amino Acids

Title:Attenuation of Diabetes-induced Cardiac and Subcellular Defects by Sulphur-containing Amino Acids

Volume: 25 Issue: 3

Author(s): Paramjit S. Tappia*, Adriana Adameova and Naranjan S. Dhalla

Affiliation:

• Asper Clinical Research Institute, St. Boniface Hospital, Winnipeg,Canada

Keywords: Sulphur-containing amino acids, Taurine, Cysteine, Diabetes mellitus, Diabetic cardiomyopathy, Preventive nutrition.

Abstract: Background: Patients with diabetes mellitus have an increased risk of mortality due to cardiovascular complications. Supplementation with specific sulphur-containing amino acids is rapidly emerging as a possible therapeutic adjuvant for diabetes and associated cardiovascular complications.

Observations: It is well-known that oxidative stress plays an important role in the pathogenesis of diabetes-induced cardiovascular disease, which is invariably associated with abnormal blood lipid profile, insulin resistance and other symptoms of metabolic syndrome. Cysteine and taurine are among the most common sulphur-containing amino acids and their cellular levels decline during diabetes that may contribute to the development of the cardiomyopathy. Although sulphur-containing agents exert multiple actions on cellular and subcellular functions in the heart, they also exhibit antioxidant properties and thus may exert beneficial effects in different pathophysiological conditions.

Conclusion: It is concluded that reduction of oxidative stress by cysteine and taurine may serve as an important mechanism for the attenuation of diabetes-induced subcellular and functional abnormalities in the heart.

Cite this article as:

Tappia S. Paramjit *, Adameova Adriana and Dhalla S. Naranjan, Attenuation of Diabetes-induced Cardiac and Subcellular Defects by Sulphur-containing Amino Acids, Current Medicinal Chemistry 2018; 25 (3) . https://dx.doi.org/10.2174/0929867324666170705115207