Method Development in Forensic Toxicology

Title:Method Development in Forensic Toxicology

Volume: 23 Issue: 36

Author(s): Frank T. Peters*, Dirk K. Wissenbach, Francesco Paolo Busardo, Emilia Marchei and Simona Pichini

Affiliation:

• Institute of Forensic Medicine, Jena University Hospital, 07740 Jena,Germany

Keywords: Forensic toxicology, method development, hyphenated methods, systematic toxicological analysis, analytical methods, forensic applications.

Abstract: Background: In the field of forensic toxicology, the quality of analytical methods is of great importance to ensure the reliability of results and to avoid unjustified legal consequences. A key to high quality analytical methods is a thorough method development.

Methods: The presented article will provide an overview on the process of developing methods for forensic applications.

Results: This includes the definition of the method’s purpose (e.g. qualitative vs quantitative) and the analytes to be included, choosing an appropriate sample matrix, setting up separation and detection systems as well as establishing a versatile sample preparation.

Conclusion: Method development is concluded by an optimization process after which the new method is subject to method validation.

Cite this article as:

Peters T. Frank *, Wissenbach K. Dirk , Busardo Paolo Francesco, Marchei Emilia and Pichini Simona , Method Development in Forensic Toxicology, Current Pharmaceutical Design 2017; 23 (36) . https://dx.doi.org/10.2174/1381612823666170622113331