摘要
癌症是世界范围内一个重大的公共卫生问题,也是美国第二大死因。虽然癌症死亡率自1991年以来下降了23%,但某些癌症的死亡率仍在上升,例如胰腺癌。迫切需要找到新的治疗方法来帮助改善这种可怕的结果。在这方面,营养在健康和疾病中的作用引起了人们的极大关注。几种饮食成分参与了代谢、生理和细胞信号传递,影响肿瘤的生长和进展。虽然脂类,特别是多不饱和脂肪酸,传统上由于其对心血管疾病的健康影响而受到研究,但现在很明显,它们可以影响广泛的细胞过程,影响范围广泛的疾病,如II型糖尿病、炎症性疾病和癌症。这些生物活性可分为:(1)膜结构和功能调节;(2)胞内信号通路;(3)转录因子活性;(4)基因表达;(5)生物活性脂质介质的产生。本文旨在对胰腺癌中多不饱和脂肪酸调控的这些潜在的作用机制和信号通路的研究现状进行综述。
关键词: 胰腺癌,ω-3脂肪酸,II型糖尿病,基因表达,上皮恶性肿瘤,信号通路。
Current Medicinal Chemistry
Title:The Complexity of Omega-3 Fatty Acid Modulation of Signaling Pathways Related to Pancreatic Cancer
Volume: 25 Issue: 22
关键词: 胰腺癌,ω-3脂肪酸,II型糖尿病,基因表达,上皮恶性肿瘤,信号通路。
摘要: Cancer is a major public health problem worldwide and is the second leading cause of death in the United States. Although cancer death rate has dropped by 23% since 1991, there are certain types of cancer for which death rates are still increasing, such as pancreatic cancer. There is an urgent need to find new therapies that could help improve this dreadful outcome. In this regard, the role of nutrition in health and disease has attracted much attention. Several dietary components are involved in metabolic, physiologic and cell signaling affecting tumor growth and progression. Although lipids, and more specifically polyunsaturated fatty acids, have been traditionally studied due to their health effects in cardiovascular disease, it is now clear that they can impact an extensive array of cellular processes that influence a wide range of diseases such as type II diabetes, inflammatory disorders and cancer. These biological activities may be grouped as regulation of: (1) membrane structure and function, (2) intracellular signaling pathways, (3) transcription factor activity, (4) gene expression, and (5) production of bioactive lipid mediators. The aim of this review is to assimilate the current state of knowledge about these potential mechanism(s) of action and signaling pathways modulated by polyunsaturated fatty acids in pancreatic cancer.
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Cite this article as:
The Complexity of Omega-3 Fatty Acid Modulation of Signaling Pathways Related to Pancreatic Cancer, Current Medicinal Chemistry 2018; 25 (22) . https://dx.doi.org/10.2174/0929867324666170616111225
DOI https://dx.doi.org/10.2174/0929867324666170616111225 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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