摘要
背景:肥胖胰岛素抵抗是包括缺血性心脏病(IHD)在内的心血管疾病最重要的危险因素之一。越来越多的证据表明,在肥胖的胰岛素抵抗状态下,心肌缺血再灌注(I/R)损伤的易感性增加。根据现有的证据,从人和动物的研究,这一综述主要集中在肥胖胰岛素抵抗对I/R侮辱的结果对心脏的影响。此外,我们还讨论了通过药物干预提高胰岛素敏感性是否能改善再灌注所致的心肌损伤。方法:以电子数据库Pubmed为语料库,以英文发表的同行评议论文为参考依据。以肥胖、胰岛素抵抗、缺血再灌注损伤和心肌梗死为关键词,进行了临床前研究和临床试验。结果:以肥胖、胰岛素抵抗和心肌缺血再灌注损伤为关键词进行了27项临床前研究,以肥胖、胰岛素抵抗和心肌梗死为关键词进行了5项临床试验。肥胖胰岛素抵抗中I/R损伤加重的潜在机制是我们综述的主要内容。结论:肥胖胰岛素抵抗状态下I/R损伤的易感性增加。然而,导致肥胖胰岛素抵抗I/R损伤加重的根本机制尚未完全阐明,但基础氧化应激增加、抗氧化能力受损、胰岛素信号传递、促生存信号和炎症增加可能发挥重要作用。
关键词: 肥胖胰岛素抵抗,缺血/再灌注,心脏,心肌梗死,缺血性心脏病,肥胖。
Current Medicinal Chemistry
Title:The Influence of Obese Insulin-Resistance on the Outcome of the Ischemia/Reperfusion Insult to the Heart
Volume: 25 Issue: 13
关键词: 肥胖胰岛素抵抗,缺血/再灌注,心脏,心肌梗死,缺血性心脏病,肥胖。
摘要: Background: Obese insulin-resistance is one of the most important risk factor for cardiovascular diseases including ischemic heart disease (IHD). Growing evidences suggest that the susceptibility to myocardial ischemia-reperfusion (I/R) injury is increased in an obese insulin-resistance condition. Based on the currently available evidence from human and animal studies, this review mainly focuses on the influence of obese insulinresistance on the outcome of the I/R insult to the heart. Moreover, we have discussed whether improving insulin sensitivity by pharmacological interventions could ameliorate reperfusion induced myocardial injury.
Methods: The electronic database Pubmed was used as the source of selected peerreviewed research articles published in English. Both pre-clinical studies and clinical trials were obtained using obesity, insulin resistance, ischemia-reperfusion injury and myocardial infarction as keywords.
Results: Twenty-seven pre-clinical studies were obtained using obesity, insulin resistance, and cardiac ischemia-reperfusion injury as keywords, and five clinical trials were obtained using obesity, insulin resistance, and myocardial infarction as keywords. The underlying mechanisms responsible for the exacerbation of I/R injury in obese insulinresistance were the main subject of our review.
Conclusion: The findings of this review suggest that the susceptibility to I/R injury is increased in an obese insulin-resistance condition. However, the underlying mechanisms responsible for the exacerbation of I/R injury in obese insulin-resistance have not been fully elucidated, but increased basal oxidative stress, the impairment of anti-oxidant capacities, insulin signaling and pro-survival signaling and increased inflammation, likely play an important role.
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Cite this article as:
The Influence of Obese Insulin-Resistance on the Outcome of the Ischemia/Reperfusion Insult to the Heart, Current Medicinal Chemistry 2018; 25 (13) . https://dx.doi.org/10.2174/0929867324666170616105639
DOI https://dx.doi.org/10.2174/0929867324666170616105639 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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