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Current Enzyme Inhibition

Editor-in-Chief

ISSN (Print): 1573-4080
ISSN (Online): 1875-6662

Research Article

Molecular Modeling Interaction Between Enzyme Diabetes Type 2 Dipeptidyl- Peptidase (DPP-4) and Main Compound of Cinnamon

Author(s): Bouchentouf Salim*, Ghalem Said, Missoum Noureddine and Allali Hocine

Volume 14, Issue 1, 2018

Page: [61 - 66] Pages: 6

DOI: 10.2174/1573408013666170613103142

Price: $65

Abstract

Background: Nowadays molecular modeling is widely used in different areas of scientific research. Especially in medical and pharmaceutical research molecular modeling allows saving time and money in conception of new drugs by comprehension of interaction between disease's enzymes and inhibitors for probable formation of stable complex. Cinnamon as famous plant and culinary spice is highly recommended in treatment of type 2 diabetes by many researchers.

Methods: By molecular modeling and molecular docking, interactions between type 2 diabetes enzyme (DPP-4) and characteristically molecules of cinnamon are studied.

Results: Molecules from different parts of cinnamon interact differently with diabetes type 2 enzyme (DPP-4) and confirm primary studies concerning cinnamon anti-diabetic effect.

Conclusion: Buds and flowers molecules of cinnamon inhibit DPP-4 enzyme better than barks commonly used as spices and traditional medicines.

Keywords: Cinnamon, diabetes, DPP4, inhibitor, MOE (Molecular Operating Environment), molecular modeling.

Graphical Abstract


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