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摘要
背景:心肌梗死或心脏手术引起的心脏缺血再灌注损伤是一个严重的临床问题。心肌氧化应激的发展是心肌缺血再灌注损伤最突出的机制之一。在这方面,已证明,R/R能增强心脏中活性氧/氮的产生,从而导致内源性自由基清除系统的氧化剂和抗氧化能力之间的不平衡。 目的:通过外源性抗氧化剂的管理增加心脏的抗氧化能力被认为是有益于我/ R. N-乙酰半胱氨酸(NAC)心和Nmercaptopropionylglycine(MPG)是两种含硫氨基酸的物质,属于外源性抗氧化剂,已经过测试,在心肌I/R损伤的保护电位广义范畴。 观察:用NAC和MPG的心已经证明这些药物预处理减轻I/R诱导的改变,肌膜,肌浆网,除了改善心脏功能的线粒体和肌原纤维。虽然实验研究揭示了有希望的数据表明NAC和英里流量在心脏I/R损伤中的有益作用,但临床试验的结果并不确凿,因为这些物质对心脏手术或心肌梗死后心脏缺血恢复的积极和无效影响都有报道。 结论:认为NAC和MPG发挥防止我/ rinduced损伤有益的影响;然而,还需要进一步的研究来确定其有效性在倒车I/R心脏异常。
关键词: 缺血再灌注,N-乙酰半胱氨酸,N-巯基丙基甘氨酸,心功能,亚细胞缺陷,心脏损伤。
Current Medicinal Chemistry
Title:Beneficial Effects of N-acetylcysteine and N-mercaptopropionylglycine on Ischemia Reperfusion Injury in the Heart
Volume: 25 Issue: 3
关键词: 缺血再灌注,N-乙酰半胱氨酸,N-巯基丙基甘氨酸,心功能,亚细胞缺陷,心脏损伤。
摘要: Background: Ischemia-reperfusion (I/R) injury of the heart as a consequence of myocardial infarction or cardiac surgery represents a serious clinical problem. One of the most prominent mechanisms of I/R injury is the development of oxidative stress in the heart. In this regard, I/R has been shown to enhance the production of reactive oxygen/nitrogen species in the heart which lead to the imbalance between the pro-oxidants and antioxidant capacities of the endogenous radical-scavenging systems.
Objectives: Increasing the antioxidant capacity of the heart by the administration of exogenous antioxidants is considered beneficial for the heart exposed to I/R. N-acetylcysteine (NAC) and Nmercaptopropionylglycine (MPG) are two sulphur containing amino acid substances, which belong to the broad category of exogenous antioxidants that have been tested for their protective potential in cardiac I/R injury.
Observations: Pretreatment of hearts with both NAC and MPG has demonstrated that these agents attenuate the I/R-induced alterations in sarcolemma, sarcoplasmic reticulum, mitochondria and myofibrils in addition to improving cardiac function. While experimental studies have revealed promising data suggesting beneficial effects of NAC and MPG in cardiac I/R injury, the results of clinical trials are not conclusive because both positive and no effects of these substances have been reported on the post-ischemic recovery of heart following cardiac surgery or myocardial infarction.
Conclusion: It is concluded that both NAC and MPG exert beneficial effects in preventing the I/Rinduced injury; however, further studies are needed to establish their effectiveness in reversing the I/R-induced abnormalities in the heart.
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Cite this article as:
Beneficial Effects of N-acetylcysteine and N-mercaptopropionylglycine on Ischemia Reperfusion Injury in the Heart, Current Medicinal Chemistry 2018; 25 (3) . https://dx.doi.org/10.2174/0929867324666170608111917
DOI https://dx.doi.org/10.2174/0929867324666170608111917 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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