Emerging Understanding of the Advantage of Small Molecules such as Hydroxypyridinones in the Treatment of Iron Overload

Robert   C.   Hider; Zu   D.   Liu

doi:10.2174/0929867033457629

Abstract

Deferiprone, a hydroxypyridin-4-one, is effective at facilitating iron removal from iron overloaded patients, when administered orally. Some problems associated with deferiprone are discussed. Hydroxypyridinone analogues with improved distribution, metabolism and affinity for iron are described. In particular the “high pFe3+” hydroxypyridin-4-ones possess considerable clinical potential.

Keywords: iron chelators, hydroxypyridinone, prodrug

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Current Medicinal Chemistry

Title: Emerging Understanding of the Advantage of Small Molecules such as Hydroxypyridinones in the Treatment of Iron Overload

Volume: 10 Issue: 12

Author(s): Robert C. Hider and Zu D. Liu

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Keywords: iron chelators, hydroxypyridinone, prodrug

Abstract: Deferiprone, a hydroxypyridin-4-one, is effective at facilitating iron removal from iron overloaded patients, when administered orally. Some problems associated with deferiprone are discussed. Hydroxypyridinone analogues with improved distribution, metabolism and affinity for iron are described. In particular the “high pFe3+” hydroxypyridin-4-ones possess considerable clinical potential.

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Hider C. Robert and Liu D. Zu, Emerging Understanding of the Advantage of Small Molecules such as Hydroxypyridinones in the Treatment of Iron Overload, Current Medicinal Chemistry 2003; 10 (12) . https://dx.doi.org/10.2174/0929867033457629