摘要
目的:本文综述了药物低温对脑血管疾病的神经保护作用及其相关副作用。 方法:采用Pubmed和Embase电子数据库进行系统文献检索,进行回顾性分析。 结果:实验研究表明,药物诱导的体温降低可减轻脑损伤,起到神经保护作用,从而降低死亡率,改善神经功能缺损。因此,药物低温具有重要的研究价值,值得进一步的考虑。然而,药物诱发的低体温也与副作用相关,例如室性心动过速,心室颤动,免疫功能受损,感染,电解质失衡,葡萄糖代谢紊乱和骨骼肌震颤。冷却效果的现有药物属于以下几类:(1)多巴胺受体激动剂; (2)大麻; (3)阿片受体; (4)香草素受体; (5)加压素(强力神经降压素受体激动剂); (6)甲状腺药物; (7)腺苷药物;和(8)嘌呤药物。
关键词: 药物诱导的治疗低温,神经保护,脑血管疾病,脑出血,脑缺血。
图形摘要
Current Drug Targets
Title:Neuroprotective Effects of Drug-Induced Therapeutic Hypothermia in Central Nervous System Diseases
Volume: 18 Issue: 12
关键词: 药物诱导的治疗低温,神经保护,脑血管疾病,脑出血,脑缺血。
摘要: Objective: This review article focuses on the neuroprotective effect of drug-induced hypothermia in cerebrovascular diseases and discusses its related side effects.
Method: A systematic literature search was performed using Pubmed and Embase electronic databases for a retrospective analysis. Results: Experimental studies have shown that drug-induced hypothermia alleviates brain damage and plays a neuroprotective role, thereby reducing mortality and ameliorating neurological deficits. Therefore, drug-induced hypothermia has an important research value and is worth further consideration in the clinical setting. However, drug-induced hypothermia is also associated with side effects, such as ventricular tachycardia, ventricular fibrillation, suppressed immune function, infection, electrolyte imbalance, glucose metabolism disorders, and skeletal muscle tremor. Existing drugs with cooling effects belong to the following categories: (1) dopamine receptor agonists; (2) cannabis; (3) opioid receptors; (4) vanilloid receptors; (5) vasopressins (potent neurotensin receptor agonists); (6) thyroid drugs; (7) adenosine drugs; and (8) purine drugs.Export Options
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Cite this article as:
Neuroprotective Effects of Drug-Induced Therapeutic Hypothermia in Central Nervous System Diseases, Current Drug Targets 2017; 18 (12) . https://dx.doi.org/10.2174/1389450118666170607104251
DOI https://dx.doi.org/10.2174/1389450118666170607104251 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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