摘要
简介:不断发展的基因治疗领域有望为癌症提供多种创新治疗方法。肿瘤细胞和微环境的遗传修饰的进展导致了更有效的治疗策略的发展,副作用更少。 材料与方法:有效交付系统的发展挑战。非病毒载体由于其生物安全性和转移不同类型核酸的能力而引起人们的关注。这些技术的例子是oligonucleoides,使用脂质体、纳米颗粒、无机材料、干细胞工程。 结论:本文综述了DNA和siRNA在细胞内向乳腺癌细胞中表达的研究进展。
关键词: 乳腺癌,非病毒传递系统,适体,基因治疗,DNA,RNA。
Current Gene Therapy
Title:Non-viral Delivery Systems for Breast Cancer Gene Therapy
Volume: 17 Issue: 2
关键词: 乳腺癌,非病毒传递系统,适体,基因治疗,DNA,RNA。
摘要: Introduction: The ever-evolving field of gene therapy promises several innovative treatments for cancer. Advances in genetic modification of tumor cells and micro environment have led to the development of more effective therapeutic strategies with fewer side effects.
Materials & Methods: The development of effective delivery system challenges, remains. Non-viral vectors are interesting due to their bio-safety and their ability to transfer different types of nucleic acids. Examples of these techniques are the use of oligonucleoides, liposomes, nanoparticles, inorganic material, and engineered stem cells. Conclusion: In this review, we focus on recent advances in the intracellular delivery of DNA and siRNA to the cancer cells with emphasis on breast cancer.Export Options
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Cite this article as:
Non-viral Delivery Systems for Breast Cancer Gene Therapy, Current Gene Therapy 2017; 17 (2) . https://dx.doi.org/10.2174/1566523217666170606124131
DOI https://dx.doi.org/10.2174/1566523217666170606124131 |
Print ISSN 1566-5232 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5631 |
Call for Papers in Thematic Issues
Programmed Cell Death Genes in Oncology: Pioneering Therapeutic and Diagnostic Frontiers (BMS-CGT-2024-HT-45)
Programmed Cell Death (PCD) is recognized as a pivotal biological mechanism with far-reaching effects in the realm of cancer therapy. This complex process encompasses a variety of cell death modalities, including apoptosis, autophagic cell death, pyroptosis, and ferroptosis, each of which contributes to the intricate landscape of cancer development and ...read more
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