安培激活蛋白激酶作为慢性肾脏病的药物靶点

Title:AMP-activated Protein Kinase as a Drug Target in Chronic Kidney Disease

Volume: 19 Issue: 6

关键词: 激活蛋白激酶，凋亡，自噬，慢性肾脏疾病，内质网应激，上皮间充质转换，哺乳动物雷帕霉素靶点，二甲双胍。

摘要: Background: Chronic kidney disease (CKD) is a condition increasingly affecting millions of individuals worldwide and is ranked as the ninth leading cause of death in the United States. AMPactivated protein kinase (AMPK) is an energy sensor that plays a pivotal role in cellular homoeostasis. Deficiency in AMPK activity and autophagic signaling, and sustained activation of mammalian target of rapamycin (mTOR) signaling and endoplasmic reticulum (ER) stress have been shown to promote epithelial-to-mesenchymal transition (EMT) and renal cell apoptosis and contribute to CKD. Emerging evidences demonstrate that AMPK acts as a modulator of the aforementioned pathways that underpin the pathophysiology of CKD. Furthermore, pharmacological activators of AMPK such as metformin have been shown to exert renoprotective effects in experimental studies and improve clinical outcomes in patients with CKD.

Objective: The current review focuses on the nephroprotective effects of AMPK and its utility as a therapeutic target for the prevention and treatment of CKD.

Cite this article as:

AMP-activated Protein Kinase as a Drug Target in Chronic Kidney Disease, Current Drug Targets 2018; 19 (6) . https://dx.doi.org/10.2174/1389450118666170601130947