High Sensitivity Troponin I and T Reflect the Presence of Obstructive and Multi-Vessel Coronary Artery Disease Being Assessed by Coronary Computed Tomography Angiography

Title:High Sensitivity Troponin I and T Reflect the Presence of Obstructive and Multi-Vessel Coronary Artery Disease Being Assessed by Coronary Computed Tomography Angiography

Volume: 18 Issue: 6

Author(s): Nadine Reckord , Michael Behnes*, Michèle Natale , Agnibh Mukherji, Jonas Rusnak, Uzair Ansari, Siegfried Lang, Ursula Hoffmann, Martin Borggrefe, Thomas Henzler, Michael Neumaier, Maximilian T. Kittel, Kambis Mashayekhi , Thomas Bertsch and Ibrahim Akin

Affiliation:

• First Department of Medicine, University Medical Centre Mannheim (UMM), Faculty of Medicine Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim,Germany

Keywords: Blood sampling, computed tomography, coronary artery disease, high sensitivity troponin, data analysis.

Abstract: Background: This study evaluates the association between high sensitivity troponin I (hsTnI) and T (hsTnT) in patients with suspected stable Coronary Artery Disease (CAD) undergoing Coronary Computed Tomography Angiography (CCTA).

Methods: Patients undergoing CCTA were enrolled prospectively. CCTA was indicated in patients with angina and a low to intermediate pre-test probability for CAD during routine clinical care. Blood samples were taken at the time of CCTA to measure cardiac biomarkers.

Results: A total of 99 patients were enrolled with 43 % revealing no CAD, 30 % with non-obstructive and 26 % with obstructive CAD. Out of these, 61 % had single-vessel and 39 % had multi-vessel CAD. Both hsTnI and hsTnT levels increased significantly according to the presence and extent of CAD (p = 0.0001) and were able to discriminate the presence of both obstructive (AUC range: 0.775 - 0.785; p = 0.0001) and multi-vessel CAD (AUC range: 0.740 - 0.749; p = 0.01). In multivariate logistic regression models adjusted for cardiovascular risk factors and NT-proBNP, both hsTn were still associated significantly with obstructive CAD (range of odds ratios (OR): 8.3-32.3; p < 0.02).

Discussion: This study shows that high sensitivity troponin I and T reflect the presence and extent of CAD being diagnosed by CCTA in patients with a low to intermediate pretest probability for CAD.

Cite this article as:

Reckord Nadine, Behnes Michael *, Natale Michèle, Mukherji Agnibh, Rusnak Jonas, Ansari Uzair , Lang Siegfried , Hoffmann Ursula , Borggrefe Martin , Henzler Thomas , Neumaier Michael , Kittel T. Maximilian , Mashayekhi Kambis , Bertsch Thomas and Akin Ibrahim, High Sensitivity Troponin I and T Reflect the Presence of Obstructive and Multi-Vessel Coronary Artery Disease Being Assessed by Coronary Computed Tomography Angiography, Current Pharmaceutical Biotechnology 2017; 18 (6) . https://dx.doi.org/10.2174/1389201018666170601082145

DOI https://dx.doi.org/10.2174/1389201018666170601082145	Print ISSN 1389-2010
Publisher Name Bentham Science Publisher	Online ISSN 1873-4316