摘要
背景:心率变异性(HRV)指数下降表明迷走神经活性低,可能与痴呆发病有关。神经退行性过程与心血管自主控制有关。 目的:本文系统回顾了老年痴呆患者自主神经功能障碍评估中HRV指标的效应量(ES)大小。 方法:参考PubMed(Medline),Web of Science,Scopus,Scielo,Lilacs和APA Psycnet。包括以英文或葡萄牙文发表的完整原创文章,调查植物神经功能紊乱与痴呆之间的关系,并使用HRV指标。 结果:搜索确定了97个可能相关的文章。在全文的筛选后,8篇文章被纳入定性分析,6篇纳入定量分析。几乎所有的指标都显示所有类型的痴呆和轻度认知功能障碍均为阴性。功率谱密度函数最常见的频段是高频率,这是由六个研究报告。阿尔茨海默病组高频功率的荟萃分析显示高度异质性和不一致的结果。 结论:负面影响大小表明所有类型的痴呆自主神经功能障碍以及轻度认知功能障碍。但是,进一步的分析是必要的,以支持这些结果。
关键词: 自主神经系统,植物神经功能紊乱,副交感神经系统,痴呆,神经变性,阿尔茨海默病。
Current Alzheimer Research
Title:Heart Rate Variability Indexes in Dementia: A Systematic Review with a Quantitative Analysis
Volume: 15 Issue: 1
关键词: 自主神经系统,植物神经功能紊乱,副交感神经系统,痴呆,神经变性,阿尔茨海默病。
摘要: Background: Decreased heart rate variability (HRV) indexes indicate low vagal activity and may be associated with development of dementia. The neurodegenerative process is associated with the cardiovascular autonomic control.
Objective: The aim of this systematic review was to investigate the effect size (ES) magnitude of the HRV indexes in the evaluation of autonomic dysfunction in older persons with dementia.
Methods: PubMed (Medline), Web of Science, Scopus, Scielo, Lilacs, and APA Psycnet were consulted. Complete original articles published in English or Portuguese, investigating the association between autonomic dysfunction and dementia, using the HRV indexes were included.
Results: The search identified 97 potentially relevant articles. After screening the full text, eight articles were included in the qualitative analysis and six were included in the quantitative analysis. Almost all indexes showed a negative ES for all types of dementia and mild cognitive impairment. The most common frequency band of the power spectrum density function was the high frequency, which was reported by six studies. The meta-analysis of high frequency power in Alzheimer's disease group showed high heterogeneity and inconsistent results.
Conclusion: The negative effect size suggests an autonomic dysfunction in all types of dementia as well as mild cognitive impairment. However, further analysis is necessary to support these results.
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Cite this article as:
Heart Rate Variability Indexes in Dementia: A Systematic Review with a Quantitative Analysis, Current Alzheimer Research 2018; 15 (1) . https://dx.doi.org/10.2174/1567205014666170531082352
DOI https://dx.doi.org/10.2174/1567205014666170531082352 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
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