摘要
背景技术经皮递送是将治疗试剂或疫苗递送至皮肤的理想方法。凭借其自我管理,经济高效和高效率的承诺,微针补片已被深入研究为治疗和疫苗接种递送平台,通过注射器取代注射。本综述旨在总结最近在应用药物和疫苗接种中微针补片的进展。 方法:我们回顾了最近发表的关于微针补片的文章,总结了其进化,分类,最新技术能力,并讨论了药物和疫苗递送中有前途的应用。 结果:随着纳米技术的飞速发展,通过从不溶性微晶切换到溶解性微针,微针斑块得到改善,其安全性也得到显着提高。作为药物输送工具,微针补丁可以提供不同物理尺寸的生物活性分子。此外,可以用DNA疫苗,亚单位抗原,灭活或活病毒疫苗包衣或包囊微针贴片。将临床结果与患者面试结果相结合,发现微针补片是可行的,并且被认为很快就可以接受医疗服务。 结论:在本次综述中,我们总结了微针片作为药物和疫苗递送载体的进展,目前和未来的应用。与传统的交付工具相比,微针补片具有许多优点,如提供无痛,无创,方便的试剂管理和交付途径,无需冷藏储存和运输,减少急性医疗废物,造成农村地区血源性传染病的传染。然而,即使在微针临床前检查方面取得了显着进展,临床应用还需进一步检测。应在疫苗学,免疫学和材料科学等多个领域进一步开展研究,以改进这一交付平台。由于其在剂量保留,安全性和治疗依从性方面的优势,预计近年来微针斑块可广泛应用于临床治疗和疫苗管理。
关键词: 微针补片,药物递送,疫苗,蜕皮递送,溶解微针。
Current Medicinal Chemistry
Title:Microneedle Patches as Drug and Vaccine Delivery Platform
Volume: 24 Issue: 22
关键词: 微针补片,药物递送,疫苗,蜕皮递送,溶解微针。
摘要: Background: Transcutaneous delivery is the ideal method for delivering therapeutic reagents or vaccines into skin. With their promise of self-administration, cost-effective and high efficiency, microneedle patches have been studied intensively as therapeutic and vaccination delivery platform that replaces injection by syringe. This review aims to summarize the recent advancements of microneedle patches in application for drugs and vaccine delivery.
Methods: We reviewed the most of recently published papers on microneedle patches, summarized their evolution, classification, state-of the-art capabilities and discussed promising application in drugs and vaccine delivery. Results: With the rapid development of nanotechnology, microneedle patches have been improved by switching from undissolving to dissolving microneedles, and their safety has also improved dramatically. As a drug delivery tool, microneedle patches can deliver bioactive molecular of different physical size. Additionally, microneedle patches can be coated or encapsulate with DNA vaccine, subunit antigen, inactivated or live virus vaccine. Combining clinical results with the results of patient interview, microneedle patches are found to be feasible and are predicated to soon be acceptable for the medical service. Conclusion: In this review, we summarized the evolution, current and future application of microneedle patches as delivery vehicle for drugs and vaccines. Compared with traditional delivery tools, microneedle patches have many advantages, such as providing pain-free, non-invasive, convenient route for reagent administration and delivery, with no cold chain required for storage and transportation as well as decreasing sharp medical waste, needle-caused injury and transmission of blood-borne infectious disease in rural area. However, even though there are dramatic progress in preclinical investigation of microneedle patches, further testing will be required for clinical application. Further research should be implemented in multiple fields, such as vaccinology, immunology, and materials science, to improve this delivery platform. Because of their advantages in dose sparing, safety and treatment compliance, microneedle patches are expected to be widely applied in clinical treatment and vaccine administration in near future.Export Options
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Cite this article as:
Microneedle Patches as Drug and Vaccine Delivery Platform, Current Medicinal Chemistry 2017; 24 (22) . https://dx.doi.org/10.2174/0929867324666170526124053
DOI https://dx.doi.org/10.2174/0929867324666170526124053 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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