Title:Promising Treatments for Obsessive-Compulsive Disorder: A Call for Additional Research
Volume: 25
Issue: 41
关键词:
强迫症,d-苯丙胺,咖啡因,兴奋剂,美金刚,昂丹司琼,经颅磁刺激.
摘要: Many patients with OCD respond partially or not at all to standard medications and
cognitive behavioral therapy approaches, making alternate treatments necessary. We review
the preliminary evidence that exists in support of the use of stimulants, high-dose caffeine,
opiates, memantine, ondansetron, ketamine, and transcranial magnetic stimulation in some
patients with OCD. Although limited by small or modest sample sizes, open-label study designs,
and brief follow-up periods, studies suggest that each of these strategies can help some
patients who have inadequately responded to first-line treatments. The existing data and the
unmet needs of OCD patients justify research attention to further test these treatments’ safety
and efficacy. Previously untested drugs also deserve attention, especially as recent research
has suggested new possible contributors to OCD pathophysiology. Similarly, psychotherapeutic
interventions beyond CBT should be investigated, and treatments with preliminary evidence
in OCD, including Acceptance Commitment Therapy, Danger Ideation Reduction
Therapy, and technology-enabled interventions like computerized CBT and Virtual Reality
Exposure Therapy, should be carefully tested.