Abstract
Significant research efforts have been concerned over the past few years to design carrier systems that could specifically deliver active agents to the tumor sites, with the purposes of maximizing the therapeutic benefits and minimizing the toxic side-effects. Hyaluronic acid is a type of polysaccharide that has been extensively studied as a selective targeting ligand to cancerous cells that overexpress its specific receptor CD44. The aim of this review is to highlight the role of HA in cancer, focusing on the recent advances of HA-functionalized lipid nanoparticles towards cancer therapy and imaging.
Keywords: Cancer targeting, CD44 receptors, Hyaluronic acid, Lipid nanoparticles, tumor, polysaccharide.
Current Pharmaceutical Design
Title:Hyaluronate-Lipid Nanohybrids: Fruitful Harmony in Cancer Targeting
Volume: 23 Issue: 35
Author(s): May S. Freag*
Affiliation:
- Department of Pharmaceutics, Faculty of Pharmacy, Alexandria University, Alexandria 21521,Egypt
Keywords: Cancer targeting, CD44 receptors, Hyaluronic acid, Lipid nanoparticles, tumor, polysaccharide.
Abstract: Significant research efforts have been concerned over the past few years to design carrier systems that could specifically deliver active agents to the tumor sites, with the purposes of maximizing the therapeutic benefits and minimizing the toxic side-effects. Hyaluronic acid is a type of polysaccharide that has been extensively studied as a selective targeting ligand to cancerous cells that overexpress its specific receptor CD44. The aim of this review is to highlight the role of HA in cancer, focusing on the recent advances of HA-functionalized lipid nanoparticles towards cancer therapy and imaging.
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Cite this article as:
Freag S. May*, Hyaluronate-Lipid Nanohybrids: Fruitful Harmony in Cancer Targeting, Current Pharmaceutical Design 2017; 23 (35) . https://dx.doi.org/10.2174/1381612823666170526103015
DOI https://dx.doi.org/10.2174/1381612823666170526103015 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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