Title:A Psycho-Behavioral Perspective on Modelling Obsessive-Compulsive Disorder (OCD) in Animals: The Role of Context
Volume: 25
Issue: 41
关键词:
强迫症,动物模型,认知,强迫症,强迫症,认知行为疗法,评论。
摘要: Obsessive-compulsive disorder is a heterogeneous and debilitating condition,
characterized by intrusive thoughts and compulsive repetition. Animal models of OCD are
important tools that have the potential to contribute significantly to our understanding of the
condition. Although there is consensus that pre-clinical models are valuable in elucidating
the underlying neurobiology in psychiatric disorders, the current paper attempts to prompt
ideas on how interpretation of animal behavior can be expanded upon to more effectively
converge with the human disorder. Successful outcomes in psychopharmacology involve
rational design and synthesis of novel compounds and their testing in well-designed animal
models. As part of a special journal issue on OCD, this paper will 1) review the psychobehavioral
aspects of OCD that are of importance on how the above ideas can be articulated,
2) briefly elaborate on general issues that are important for the development of animal models
of OCD, with a particular focus on the role and importance of context, 3) propose why
translational progress may often be less than ideal, 4) highlight some of the significant contributions
afforded by animal models to advance understanding, and 5) conclude by identifying
novel behavioral constructs for future investigations that may contribute to the face, predictive
and construct validity of OCD animal models. We base these targets on an integrative
approach to face and construct validity, and note that the issue of treatment-resistance in
the clinical context should receive attention in current animal models of OCD.