Recent Synthetic Approaches to N,N-Dimethyl-β-Ketoenamines

Title:Recent Synthetic Approaches to N,N-Dimethyl-β-Ketoenamines

Volume: 21 Issue: 21

Author(s): Hatem M. Gaber*, Zeinab A. Muhammad, Sobhi M. Gomha*, Thoraya A. Farghaly and Mark C. Bagley

Affiliation:

• National Organization for Drug Control and Research (NODCAR), P.O.Box 29, Cairo,Egypt

• Department of Chemistry, Faculty of Science, Cairo University, Giza, 12613, Egypt and National Organization for Drug Control and Research (NODCAR), P.O. Box 29, Cairo,Egypt

Keywords: N, N-dimethylenamino-ketones, DMF-DMA, condensation reactions, addition reactions, geometrical isomers, synthetic approaches.

Abstract: Background: N, N-dimethyl-β-ketoenamines have proven to be of biological interest and provide an access to new class of biologically active heterocyclic compounds for biomedical applications.

Objective: It is substantial and very helpful for the scientific researchers,interested in the chemistry of enaminones to collect all methods for the preparation of different types of enaminones in one review.

Conclusion: This review provides an up to date information about the recent progress in synthetic approaches to N, N-dimethyl-β-ketoenamines, mainly using N, N-dimethylformamide dimethylacetal (DMF-DMA) as an efficient β-(dimethylamino)methylenating agent. The bibliography includes 166 references which have been published during the period from 1998 to the mid of 2017.

Cite this article as:

Gaber M. Hatem *, Muhammad A. Zeinab , Gomha M. Sobhi *, Farghaly A. Thoraya and Bagley C. Mark , Recent Synthetic Approaches to N,N-Dimethyl-β-Ketoenamines, Current Organic Chemistry 2017; 21 (21) . https://dx.doi.org/10.2174/1385272821666170523115019